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LOCUS WP_003115063 919 aa linear BCT 19-FEB-2025 aeruginosa]. ACCESSION WP_003115063 VERSION WP_003115063.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 919) AUTHORS Gao,R., Bouillet,S. and Stock,A.M. TITLE Structural Basis of Response Regulator Function JOURNAL Annu Rev Microbiol 73, 175-197 (2019) PUBMED 31100988 REFERENCE 2 (residues 1 to 919) AUTHORS Ortet,P., Whitworth,D.E., Santaella,C., Achouak,W. and Barakat,M. TITLE P2CS: updates of the prokaryotic two-component systems database JOURNAL Nucleic Acids Res 43 (Database issue), D536-D541 (2015) PUBMED 25324303 REFERENCE 3 (residues 1 to 919) AUTHORS Attwood,P.V. TITLE Histidine kinases from bacteria to humans JOURNAL Biochem Soc Trans 41 (4), 1023-1028 (2013) PUBMED 23863173 REFERENCE 4 (residues 1 to 919) AUTHORS Galperin,M.Y. TITLE Diversity of structure and function of response regulator output domains JOURNAL Curr Opin Microbiol 13 (2), 150-159 (2010) PUBMED 20226724 REFERENCE 5 (residues 1 to 919) AUTHORS Galperin,M.Y. TITLE Structural classification of bacterial response regulators: diversity of output domains and domain combinations JOURNAL J Bacteriol 188 (12), 4169-4182 (2006) PUBMED 16740923 REFERENCE 6 (residues 1 to 919) AUTHORS Anantharaman,V. and Aravind,L. TITLE Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria JOURNAL BMC Genomics 4 (1), 34 (2003) PUBMED 12914674 REMARK Publication Status: Online-Only REFERENCE 7 (residues 1 to 919) AUTHORS Dutta,R. and Inouye,M. TITLE GHKL, an emergent ATPase/kinase superfamily JOURNAL Trends Biochem Sci 25 (1), 24-28 (2000) PUBMED 10637609 REFERENCE 8 (residues 1 to 919) AUTHORS Stock,A.M., Robinson,V.L. and Goudreau,P.N. TITLE Two-component signal transduction JOURNAL Annu Rev Biochem 69, 183-215 (2000) PUBMED 10966457 REFERENCE 9 (residues 1 to 919) AUTHORS Stock,J. TITLE Signal transduction: Gyrating protein kinases JOURNAL Curr Biol 9 (10), R364-R367 (1999) PUBMED 10339418 REFERENCE 10 (residues 1 to 919) AUTHORS Alex,L.A. and Simon,M.I. TITLE Protein histidine kinases and signal transduction in prokaryotes and eukaryotes JOURNAL Trends Genet 10 (4), 133-138 (1994) PUBMED 8029829 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 13737002 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..919 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..919 /product="hybrid sensor histidine kinase/response regulator" /EC_number="2.7.13.3" /GO_function="GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]" /GO_function="GO:0000156 - phosphorelay response regulator activity [Evidence IEA]" /GO_function="GO:0004673 - protein histidine kinase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0007165 - signal transduction [Evidence IEA]" /calculated_mol_wt=101763 Region 39..164 /region_name="7TMR-DISMED2" /note="7TMR-DISM extracellular 2; pfam07696" /db_xref="CDD:429601" Region 183..383 /region_name="7TMR-DISM_7TM" /note="7TM diverse intracellular signalling; pfam07695" /db_xref="CDD:429600" Region <395..910 /region_name="PRK11107" /note="hybrid sensory histidine kinase BarA; Provisional" /db_xref="CDD:236848" ORIGIN 1 msrlclvlll lccalparaq ppapldgedl rlslgayaey yrdaggkarl gdilalpaqa 61 faalrgdhan fgknaaawwf rvrldnrnga dlagflevny pllddlkvyl ltadgrieqq 121 esgdlfafsq rpvqvrnfwf plrlppgest lllrvqstst vylplyfsty aasaasqetl 181 mgfngafygv lfglfcynlf lfvslreaty awyllynlsl glfsasfdgl lfkllpghva 241 lesagiyllm ylsclvsiqf srgylytrrd fprldrflrg lllacvvlla seplvglraw 301 nvlasltvml vslslllagv hvwrqglryg lyyilawgal llsflvttaa slgfelfglf 361 gssvvkigmt velvtlsigl adrinalkee gfrsrqaaeq arveneaksr flakmsheir 421 tplngvlgml qllrdtpldr gqaayvetia ssgsalmsvi ndildyarie sgklhlerid 481 fdleellsdt lalfsaqave krlhlhlgld rgvprrlngd ptrlrqvlmn llsnalkfta 541 eghvavrvqr rfdeggrerl lysvsdsgig isaqaqktlf esfsqadsst trryggsglg 601 laisrelvqm mggrievsse pgkgtrfsvd lplspaldag eadelaqllq hrpallased 661 nltldclqal lerwglrver clqprrlnay ledfsappll vlaapwpgpp siwldtlyaq 721 leqgqrilll cppqhcqdlp pheglrllal aqpvavkalr eallelyrer rrqpgrssea 781 apderppdap cilvaednpv nqlvvrgfla krgyavrlag ngrlaldeyl rdpngiqlil 841 mdgempemdg featrlirre eraqgwprvp ivaltahild ehrragieag mdaylgkpvd 901 raelyatler llgqpsrqa