MFS transporter [Pseudomonas aeruginosa].

LOCUS       WP_003114961             480 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_003114961
VERSION     WP_003114961.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 480)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 480)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 480)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..480
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50276
     Region          18..448
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(25..26,29..30,33,65,115..116,118..120,123,143,
                     146..147,150,281,284..285,288..290,293,321,325,381..382,
                     386,390,406,409..410,413..414,417)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mpstvsssrl glaglcilla gqllpmidfs ivnvaldala hslgasetel elivavygva
       61 favclamggr lgdnygrrrl fvlgvalfav asllcglags vwlllvaral qgvgaalvvp
      121 qilatlhvsl sghahsrala aygaigglaf vvgqvlggfl vsadigglgw rsvflinlpi
      181 clgillcsrr wvpetraeha arvdapgtll laalilclll plalgpslhw swpcalllaa
      241 avpllawlwr telrqerrqa wpllppsllr lpsirfglll ailffacwsg fmfalalalq
      301 agaglspvqa gnafialgas yfvsalltar vaarigpvrl lllgcviqmc gllglmltlq
      361 rvwpqpgiln lapatlvigf gqafivssff riglsevpaa qagagsamla tvqqaslglg
      421 sallgavfah rlerhgdyle atqttlavef vlmtlllgat clfylrrvrt vplrcdspgn