MFS transporter [Pseudomonas aeruginosa].

LOCUS       WP_003114873             471 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_003114873
VERSION     WP_003114873.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 471)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 471)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 471)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..471
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49011
     Region          15..404
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(22..23,26..27,30,62,112..113,115..117,120,141,
                     144..145,148,273,276..277,280..282,285,313,317,370..371,
                     375,379,395,398..399,402..403)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mtdraapsnw mlallacaql iialdativf valpeisral dfsaqrlqwv vsaytvafgg
       61 flllggratd llgrrrmyvl gqslyalasl agglaqselp lilaravqgl ggallfpatl
      121 alignhfaeg parnralaiw siasafglal gsalggalte lfgwasiflv nvplagaaal
      181 lalrlipada rrqrgrrfdl agaltvtaga tllvfalvqg pesgwdapsv rfglylsvpl
      241 llaflaiehy srdplmplrl lgnrnlqvam lltaifmssy gvqyyflaiy fqsvygysvl
      301 qtglaflpat llctlgirva erllarhgar atlvaglllg alglgllaac lplgrgflal
      361 lpaivilsvg qgmtwtamwv saasgvdpae qgvasgmasm tqqiggalgl allvalanaq
      421 vrgadaasll asqargiewv talsallalf gaalalrlrr eepaalqpsr g