NADPH-dependent 7-cyano-7-deazaguanine reductase QueF [Pseudomonas

LOCUS       WP_003114774             276 aa            linear   BCT 28-FEB-2022
            aeruginosa].
ACCESSION   WP_003114774
VERSION     WP_003114774.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 276)
  AUTHORS   Kim,Y., Zhou,M., Moy,S., Morales,J., Cunningham,M.A. and
            Joachimiak,A.
  TITLE     High-resolution structure of the nitrile reductase QueF combined
            with molecular simulations provide insight into enzyme mechanism
  JOURNAL   J Mol Biol 404 (1), 127-137 (2010)
   PUBMED   20875425
REFERENCE   2  (residues 1 to 276)
  AUTHORS   Van Lanen,S.G., Reader,J.S., Swairjo,M.A., de Crecy-Lagard,V.,
            Lee,B. and Iwata-Reuyl,D.
  TITLE     From cyclohydrolase to oxidoreductase: discovery of nitrile
            reductase activity in a common fold
  JOURNAL   Proc Natl Acad Sci U S A 102 (12), 4264-4269 (2005)
   PUBMED   15767583
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR03138.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..276
                     /gene="queF"
     Protein         1..276
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /EC_number="1.7.1.13"
                     /GO_function="GO:0033739 - preQ1 synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043867 - 7-cyano-7-deazaguanine
                     tRNA-ribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /note="Catalyzes the NADPH-dependent reduction of
                     7-cyano-7-deazaguanine (preQ0) to
                     7-aminomethyl-7-deazaguanine (preQ1) in queuosine
                     biosynthesis"
                     /calculated_mol_wt=30717
     Region          4..276
                     /region_name="queF"
                     /note="7-cyano-7-deazaguanine reductase; Provisional;
                     PRK11792"
                     /db_xref="CDD:236986"
ORIGIN      
        1 mqhpaehspl gktseyvssy tpsllfpisr takwaelgls aetlpyrgvd iwncyelswl
       61 tpagkpvvai gefsipadsp niiesksfkl ylnslnqsaf dsrealravl qkdlsaavga
      121 pvgvrlrsld evaeegigrl pgrcideldi avdgyeqprp ellrcdagri veeqlyshll
      181 ksncpvtgqp dwgtlvvdyr gpaldpasll aylvsfrqhq dfheqcveri fldlqrllqp
      241 qalsvyaryv rrggldinpy rslaevapdn rrlvrq