phenylalanine--tRNA ligase subunit alpha [Pseudomonas aeruginosa].

LOCUS       WP_003114409             338 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_003114409
VERSION     WP_003114409.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 338)
  AUTHORS   Abibi,A., Ferguson,A.D., Fleming,P.R., Gao,N., Hajec,L.I., Hu,J.,
            Laganas,V.A., McKinney,D.C., McLeod,S.M., Prince,D.B., Shapiro,A.B.
            and Buurman,E.T.
  TITLE     The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA
            synthetase druggability
  JOURNAL   J Biol Chem 289 (31), 21651-21662 (2014)
   PUBMED   24936059
REFERENCE   2  (residues 1 to 338)
  AUTHORS   Mermershtain,I., Finarov,I., Klipcan,L., Kessler,N., Rozenberg,H.
            and Safro,M.G.
  TITLE     Idiosyncrasy and identity in the prokaryotic Phe-system: crystal
            structure of E. coli phenylalanyl-tRNA synthetase complexed with
            phenylalanine and AMP
  JOURNAL   Protein Sci 20 (1), 160-167 (2011)
   PUBMED   21082706
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00468.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..338
                     /gene="pheS"
     Protein         1..338
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=37933
     Region          1..338
                     /region_name="PheS"
                     /note="Phenylalanyl-tRNA synthetase alpha subunit
                     [Translation, ribosomal structure and biogenesis];
                     COG0016"
                     /db_xref="CDD:439787"
ORIGIN      
        1 menldalvsq aleavrhted vnaleqirvh ylgkkgeltq vmktlgdlpa eerpkvgali
       61 nvakekvqdv lnarkteleg aalaarlaae ridvtlpgrg qlsgglhpvt rtlerieqcf
      121 srigyevaeg peveddyhnf ealnipghhp aramhdtfyf nanmllrtht spvqvrtmes
      181 qqppirivcp grvyrcdsdl thspmfhqve gllvdegvsf adlkgtieef lraffekqle
      241 vrfrpsffpf tepsaevdiq cvicsgngcr vckqtgwlev mgcgmvhpnv lrmsnidpek
      301 fqgfafgmga erlamlrygv ndlrlffdnd lrflgqfr