MULTISPECIES: bifunctional phosphopantothenoylcysteine

LOCUS       WP_003114358             402 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC
            [Pseudomonas].
ACCESSION   WP_003114358
VERSION     WP_003114358.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 402)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 402)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..402
                     /gene="coaBC"
     Protein         1..402
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43002
     Region          4..401
                     /region_name="CoaBC"
                     /note="Phosphopantothenoylcysteine
                     synthetase/decarboxylase CoaBC [Coenzyme transport and
                     metabolism]; COG0452"
                     /db_xref="CDD:440221"
ORIGIN      
        1 mqrlyrkriv lgvgggiaay ksaelvrrlr dqgaevrvvm tqggrefitp ltlqalsghp
       61 vhtdlldpaa eaamghiela rwadlvliap atadlmarlv qgvandlltt lvlatdaqia
      121 lapamnqamw rdtatqanae llrqrgfhlf gpaagsqacg dvglgrmlea eelaqraadc
      181 fqrqaltgvh vlitagptqe nidpvryitn hssgkmgfal aeaaveagar vtlvtgpvhl
      241 ptpdrvqrvd vvsardmlaa ceaampcdll iasaavadyr pevvaahklk kdptsgegll
      301 lqlvrnpdil atlaqredrp fsvgfaaete nlldyaarkl kdknldliva ndvanpsigf
      361 nsdenaitvi drdlhpstfa qtskgkiarq lvafiadrln qq