3-hydroxyisobutyrate dehydrogenase [Pseudomonas aeruginosa].

LOCUS       WP_003114168             298 aa            linear   BCT 01-JUL-2024
ACCESSION   WP_003114168
VERSION     WP_003114168.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 298)
  AUTHORS   Hawes,J.W., Harper,E.T., Crabb,D.W. and Harris,R.A.
  TITLE     Structural and mechanistic similarities of 6-phosphogluconate and
            3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the
            3-hydroxyacid dehydrogenases
  JOURNAL   FEBS Lett 389 (3), 263-267 (1996)
   PUBMED   8766712
REFERENCE   2  (residues 1 to 298)
  AUTHORS   Steele,M.I., Lorenz,D., Hatter,K., Park,A. and Sokatch,J.R.
  TITLE     Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO
            encoding methylmalonate-semialdehyde dehydrogenase and
            3-hydroxyisobutyrate dehydrogenase
  JOURNAL   J Biol Chem 267 (19), 13585-13592 (1992)
   PUBMED   1339433
REFERENCE   3  (residues 1 to 298)
  AUTHORS   Rougraff,P.M., Zhang,B., Kuntz,M.J., Harris,R.A. and Crabb,D.W.
  TITLE     Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate
            dehydrogenase. Evidence for its evolutionary relationship to other
            pyridine nucleotide-dependent dehydrogenases
  JOURNAL   J Biol Chem 264 (10), 5899-5903 (1989)
   PUBMED   2647728
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01692.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..298
                     /gene="mmsB"
     Protein         1..298
                     /product="3-hydroxyisobutyrate dehydrogenase"
                     /EC_number="1.1.1.31"
                     /GO_function="GO:0008442 - 3-hydroxyisobutyrate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0006574 - valine catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=30623
     Region          6..292
                     /region_name="garR"
                     /note="tartronate semialdehyde reductase; Provisional;
                     cl42929"
                     /db_xref="CDD:456274"
ORIGIN      
        1 mkqiafiglg hmgapmatnl lkagyllnvf dlvqsavdgl vaagasaars ardavqgadv
       61 vismlpasqh veglyldddg llahiapgtl vlecstiapt sarkihaaar erglamldap
      121 vsggtagaaa gtltfmvggd aealekarpl feamgrnifh agpdgagqva kvcnnqllav
      181 lmigtaeama lgvangleak vlaeimrrss ggnwalevyn pwpgvmenap asrdysggfm
      241 aqlmakdlgl aqeaaqasas stpmgslals lyrlllkqgy aerdfsvvqk lfdptqgq