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LOCUS WP_003114080 1159 aa linear BCT 02-MAR-2025 regulator [Pseudomonas aeruginosa]. ACCESSION WP_003114080 VERSION WP_003114080.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 1159) AUTHORS Stuffle,E.C., Johnson,M.S. and Watts,K.J. TITLE PAS domains in bacterial signal transduction JOURNAL Curr Opin Microbiol 61, 8-15 (2021) PUBMED 33647528 REFERENCE 2 (residues 1 to 1159) AUTHORS Gao,R., Bouillet,S. and Stock,A.M. TITLE Structural Basis of Response Regulator Function JOURNAL Annu Rev Microbiol 73, 175-197 (2019) PUBMED 31100988 REFERENCE 3 (residues 1 to 1159) AUTHORS Ortet,P., Whitworth,D.E., Santaella,C., Achouak,W. and Barakat,M. TITLE P2CS: updates of the prokaryotic two-component systems database JOURNAL Nucleic Acids Res 43 (Database issue), D536-D541 (2015) PUBMED 25324303 REFERENCE 4 (residues 1 to 1159) AUTHORS Attwood,P.V. TITLE Histidine kinases from bacteria to humans JOURNAL Biochem Soc Trans 41 (4), 1023-1028 (2013) PUBMED 23863173 REFERENCE 5 (residues 1 to 1159) AUTHORS Galperin,M.Y. TITLE Diversity of structure and function of response regulator output domains JOURNAL Curr Opin Microbiol 13 (2), 150-159 (2010) PUBMED 20226724 REFERENCE 6 (residues 1 to 1159) AUTHORS Galperin,M.Y. TITLE Structural classification of bacterial response regulators: diversity of output domains and domain combinations JOURNAL J Bacteriol 188 (12), 4169-4182 (2006) PUBMED 16740923 REFERENCE 7 (residues 1 to 1159) AUTHORS Hefti,M.H., Francoijs,K.J., de Vries,S.C., Dixon,R. and Vervoort,J. TITLE The PAS fold. A redefinition of the PAS domain based upon structural prediction JOURNAL Eur J Biochem 271 (6), 1198-1208 (2004) PUBMED 15009198 REFERENCE 8 (residues 1 to 1159) AUTHORS Dutta,R. and Inouye,M. TITLE GHKL, an emergent ATPase/kinase superfamily JOURNAL Trends Biochem Sci 25 (1), 24-28 (2000) PUBMED 10637609 REFERENCE 9 (residues 1 to 1159) AUTHORS Stock,A.M., Robinson,V.L. and Goudreau,P.N. TITLE Two-component signal transduction JOURNAL Annu Rev Biochem 69, 183-215 (2000) PUBMED 10966457 REFERENCE 10 (residues 1 to 1159) AUTHORS Stock,J. TITLE Signal transduction: Gyrating protein kinases JOURNAL Curr Biol 9 (10), R364-R367 (1999) PUBMED 10339418 REFERENCE 11 (residues 1 to 1159) AUTHORS Ponting,C.P. and Aravind,L. TITLE PAS: a multifunctional domain family comes to light JOURNAL Curr Biol 7 (11), R674-R677 (1997) PUBMED 9382818 REFERENCE 12 (residues 1 to 1159) AUTHORS Alex,L.A. and Simon,M.I. TITLE Protein histidine kinases and signal transduction in prokaryotes and eukaryotes JOURNAL Trends Genet 10 (4), 133-138 (1994) PUBMED 8029829 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11586208 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..1159 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..1159 /product="PAS domain-containing hybrid sensor histidine kinase/response regulator" /EC_number="2.7.13.3" /GO_function="GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]" /GO_function="GO:0000156 - phosphorelay response regulator activity [Evidence IEA]" /GO_function="GO:0004673 - protein histidine kinase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0007165 - signal transduction [Evidence IEA]" /calculated_mol_wt=127322 Region 7..511 /region_name="SLC5sbd" /note="Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; cd10322" /db_xref="CDD:271357" Site order(47,50,339,342..343) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271357" Region 644..758 /region_name="PAS_7" /note="PAS fold; pfam12860" /db_xref="CDD:432837" Region <767..1017 /region_name="BaeS" /note="Signal transduction histidine kinase [Signal transduction mechanisms]; COG0642" /db_xref="CDD:440407" Region 1035..1157 /region_name="CheY" /note="CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms]; COG0784" /db_xref="CDD:440547" ORIGIN 1 mslsigliav valvymailf aiafygdrrr tplsprlraw vyslslavyc tswtffgavg 61 qatdqlwsfl piylgpvllm lfapwvlqkm imiskqenit siadfiaary gksqalavvv 121 alicmvgvlp yialqlkgiv lgvnlligsg adstgtraqd talivslvla lftivfgtrs 181 ldvtehhrgm vlaiafeslv kltaflavgi fatfglydgf adlfsqaraa pqladyweet 241 vhwpamllqt gvamtaimcl prqfhvtvve nieprdlnla rwvfpiylvl aalfvvpial 301 agqlhlpagv mpdsfvislp laeahpalal lafiggasaa tgmvivasva lstmvsndml 361 lpwllrrrek dterpfeafr hwlltvrrvs iavilllayv ayrllgssas latigqiafa 421 aiaqlgpami galywkqanr rgvfaglaag sllwaytlvl pvvakglgwp leripgltwl 481 asnpfglpie pltqgvlisl vgnfalfglv svlsrtrvse hwqasrfigq eisqrqnsrf 541 mlavqvedll mlaarfvgee rarqsfirfa yrqgkgftpn qtannewiah terllagvlg 601 assaravvka aiegremqve dvvriadeas evlqfnrall qgaienitqg isvvdqslrl 661 vawnhrylel feypdgliyv grpiadiiry nadrglcgpg dpdmhvakrl ywmrqgtpht 721 serlfpngrv ielignpmpg ggfvmsftdi tayreaeqgl kganesleqr vqertqelsq 781 lnqelseaks naeaanqskt rflaavshdl mqplnaarlf saalahqdal pgevrdlvqh 841 ldsslrsaed litdlldisr lesgrvsaer npfplnnlyd algvefkala qeqglhfrlr 901 gsqlrvdsdi kllrrilqnf ltnafryakg hvllgvrred gylrlevwdq gpgippdkqk 961 vifeefkrld shqtraekgl glglaiadrl ckvlghplev rswpgkgsvf svrvplarqa 1021 ppalanghka epaqalngaq vlcvdnedsi lagmnsllsr wgcqvwtars reecatllds 1081 emrpqlalid yhlddgetgt qlmawlrtrl gepvpgvvis adarpelvae ihaagldyls 1141 kpvkpaalra llsrhlslr