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LOCUS WP_003113880 357 aa linear BCT 19-FEB-2025 enzyme AdaA [Pseudomonas]. ACCESSION WP_003113880 VERSION WP_003113880.1 KEYWORDS RefSeq. SOURCE Pseudomonas ORGANISM Pseudomonas Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae. REFERENCE 1 (residues 1 to 357) AUTHORS Aravind,L., Anantharaman,V., Balaji,S., Babu,M.M. and Iyer,L.M. TITLE The many faces of the helix-turn-helix domain: transcription regulation and beyond JOURNAL FEMS Microbiol Rev 29 (2), 231-262 (2005) PUBMED 15808743 REFERENCE 2 (residues 1 to 357) AUTHORS Rosinski,J.A. and Atchley,W.R. TITLE Molecular evolution of helix-turn-helix proteins JOURNAL J Mol Evol 49 (3), 301-309 (1999) PUBMED 10473770 REFERENCE 3 (residues 1 to 357) AUTHORS Wintjens,R. and Rooman,M. TITLE Structural classification of HTH DNA-binding domains and protein-DNA interaction modes JOURNAL J Mol Biol 262 (2), 294-313 (1996) PUBMED 8831795 REFERENCE 4 (residues 1 to 357) AUTHORS Morohoshi,F., Hayashi,K. and Munakata,N. TITLE Molecular analysis of Bacillus subtilis ada mutants deficient in the adaptive response to simple alkylating agents JOURNAL J Bacteriol 173 (24), 7834-7840 (1991) PUBMED 1744039 REFERENCE 5 (residues 1 to 357) AUTHORS Morohoshi,F., Hayashi,K. and Munakata,N. TITLE Bacillus subtilis ada operon encodes two DNA alkyltransferases JOURNAL Nucleic Acids Res 18 (18), 5473-5480 (1990) PUBMED 2120677 REFERENCE 6 (residues 1 to 357) AUTHORS Brennan,R.G. and Matthews,B.W. TITLE The helix-turn-helix DNA binding motif JOURNAL J Biol Chem 264 (4), 1903-1906 (1989) PUBMED 2644244 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11450612 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..357 /organism="Pseudomonas" /db_xref="taxon:286" Protein 1..357 /product="bifunctional transcriptional activator/DNA repair enzyme AdaA" /EC_number="2.1.1.-" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0008168 - methyltransferase activity [Evidence IEA]" /GO_process="GO:0006281 - DNA repair [Evidence IEA]" /GO_process="GO:0032259 - methylation [Evidence IEA]" /calculated_mol_wt=38992 Region 9..356 /region_name="AdaA" /note="Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair]; COG2169" /db_xref="CDD:441772" ORIGIN 1 mshaalflpl pdddtlyaal lardpaydgf afvgvkstgv fcrltcpark pkrentlffd 61 sikgcveagf rpclrcrple rlgtqgplvs dllqrlgrqp qrrwfeddla algydpstvr 121 rafkrefgvt flemarlrrl gqvaerlssg arvidaqlda sfdsdsgfrs afarllgepp 181 sqlrgrellk adwlqtplga mlavadaqal hlleffdrpa lsgelkrlqk ssgssigfgr 241 fasidrieae ladyfggtpv rfqtplalna saftrtvwqa lrevpcgstq syaglarsig 301 spssvravar anganqiaiv ipchrvigsd gsltgygggl wrkrwllehe rrmgaag