MULTISPECIES: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

LOCUS       WP_003113864             396 aa            linear   BCT 20-NOV-2023
            [Pseudomonas].
ACCESSION   WP_003113864
VERSION     WP_003113864.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Haymond,A., Johny,C., Dowdy,T., Schweibenz,B., Villarroel,K.,
            Young,R., Mantooth,C.J., Patel,T., Bases,J., San Jose,G.,
            Jackson,E.R., Dowd,C.S. and Couch,R.D.
  TITLE     Kinetic characterization and allosteric inhibition of the Yersinia
            pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP
            synthase)
  JOURNAL   PLoS One 9 (8), e106243 (2014)
   PUBMED   25171339
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003938.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05447
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..396
                     /gene="ispC"
     Protein         1..396
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /EC_number="1.1.1.267"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=42378
     Region          4..395
                     /region_name="Dxr"
                     /note="1-deoxy-D-xylulose 5-phosphate reductoisomerase
                     [Lipid transport and metabolism]; COG0743"
                     /db_xref="CDD:440506"
ORIGIN      
        1 msrpqrisvl gatgsiglst ldvvqrhpdr yeafaltgfs rlaelealcl rhrpvyavvp
       61 eqaaaialqg slaaagirtr vlfgeqalce vasapevdmv maaivgaagl pstlaaveag
      121 krvllankea lvmsgalfmq avkrsgavll pidsehnaif qslprnyadg lervgvrril
      181 ltasggpfre tpleqlasvt peqacahpnw smgrkisvds asmmnkglel ieacwlfdaq
      241 psqvevvihp qsvihsmvdy vdgsviaqlg npdmrtpisy amawperids gvspldmfav
      301 grldfqrpde qrfpclrlas qaaetggsap amlnaaneva vaaflerhir fsdiaviied
      361 vlnreavtav esldqvlaad rrarsvagqw ltrhag