MULTISPECIES: T3SS effector bifunctional cytotoxin exoenzyme S

LOCUS       WP_003113791             453 aa            linear   BCT 20-NOV-2023
            [Pseudomonas].
ACCESSION   WP_003113791
VERSION     WP_003113791.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR008172
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..453
                     /gene="exoS"
     Protein         1..453
                     /product="T3SS effector bifunctional cytotoxin exoenzyme
                     S"
                     /calculated_mol_wt=48171
     Region          105..224
                     /region_name="ToxGAP"
                     /note="GTPase-activating protein (GAP) domain found in
                     bacterial cytotoxins, ExoS, SptP, and YopE. Part of
                     protein secretion system; stimulates Rac1- dependent
                     cytoskeletal changes that promote bacterial
                     internalization; cd00219"
                     /db_xref="CDD:119405"
     Site            order(119,140..142,147,150)
                     /site_type="active"
                     /note="switch II binding region [active]"
                     /db_xref="CDD:119405"
     Site            order(141,146)
                     /site_type="other"
                     /note="Rac1 P-loop interaction site [polypeptide binding]"
                     /db_xref="CDD:119405"
     Site            order(146,186..188)
                     /site_type="other"
                     /note="GTP binding residues [chemical binding]"
                     /db_xref="CDD:119405"
     Site            order(146,150,183)
                     /site_type="active"
                     /note="switch I binding region [active]"
                     /db_xref="CDD:119405"
     Region          243..429
                     /region_name="ADPrib_exo_Tox"
                     /note="ADP-ribosyltransferase exoenzyme; pfam03496"
                     /db_xref="CDD:427336"
     Site            order(272,285,319,343..345,357,381,390)
                     /site_type="active"
                     /db_xref="CDD:238144"
     Site            285
                     /site_type="active"
                     /note="conformational flexibility of ligand binding pocket
                     [active]"
                     /db_xref="CDD:238144"
     Site            order(376,379,381)
                     /site_type="active"
                     /note="ADP-ribosylating toxin turn-turn motif [active]"
                     /db_xref="CDD:238144"
ORIGIN      
        1 mhiqslqqsp sfavelhqaa sgrlgqiear qvatpseaqq laqrqdapkg egllarlgaa
       61 lvrpfvaimd wlgkllgsha rtgpqpsqda qpavmssavv fkqmvlqqal pmtlkgldka
      121 selatltpeg larehsrlas gdgalrslst alagiragsq veesriqagr llersiggia
      181 lqqwgttgga asqlvldasp elrreitdql hqvmsevall rqavesevsr vsadkaladg
      241 lvkrfgadae kylgrqpggi hsdaevmalg lytgihyadl nralrqgqel dagqklidqg
      301 msaafeksgq aeqvvktfrg trggdafnav eegkvghddg ylstslnpgv arsfgqgtis
      361 tvfgrsgidv sgisnyknek eilynketdm rvllsasdeq gvtrrvleea algeqsghsq
      421 glldaldlas kpersgevqe qdvrlrmrgl dla