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LOCUS WP_003113747 565 aa linear BCT 23-DEC-2024 [Pseudomonas]. ACCESSION WP_003113747 VERSION WP_003113747.1 KEYWORDS RefSeq. SOURCE Pseudomonas ORGANISM Pseudomonas Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae. REFERENCE 1 (residues 1 to 565) AUTHORS Shalaby,M.W., Dokla,E.M.E., Serya,R.A.T. and Abouzid,K.A.M. TITLE Penicillin binding protein 2a: An overview and a medicinal chemistry perspective JOURNAL Eur J Med Chem 199, 112312 (2020) PUBMED 32442851 REFERENCE 2 (residues 1 to 565) AUTHORS Shaku,M., Ealand,C., Matlhabe,O., Lala,R. and Kana,B.D. TITLE Peptidoglycan biosynthesis and remodeling revisited JOURNAL Adv Appl Microbiol 112, 67-103 (2020) PUBMED 32762868 REFERENCE 3 (residues 1 to 565) AUTHORS Sauvage,E., Kerff,F., Terrak,M., Ayala,J.A. and Charlier,P. TITLE The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis JOURNAL FEMS Microbiol Rev 32 (2), 234-258 (2008) PUBMED 18266856 REMARK Erratum:[FEMS Microbiol Rev. 2008 May;32(3):556] REFERENCE 4 (residues 1 to 565) AUTHORS Zapun,A., Contreras-Martel,C. and Vernet,T. TITLE Penicillin-binding proteins and beta-lactam resistance JOURNAL FEMS Microbiol Rev 32 (2), 361-385 (2008) PUBMED 18248419 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11433609 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..565 /organism="Pseudomonas" /db_xref="taxon:286" Protein 1..565 /product="peptidoglycan D,D-transpeptidase FtsI family protein" /EC_number="3.4.16.4" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0008658 - penicillin binding [Evidence IEA]" /GO_function="GO:0008955 - peptidoglycan glycosyltransferase activity [Evidence IEA]" /GO_function="GO:0009002 - serine-type D-Ala-D-Ala carboxypeptidase activity [Evidence IEA]" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_process="GO:0009252 - peptidoglycan biosynthetic process [Evidence IEA]" /GO_process="GO:0051301 - cell division [Evidence IEA]" /GO_process="GO:0071555 - cell wall organization [Evidence IEA]" /calculated_mol_wt=60970 Region 1..548 /region_name="FtsI" /note="Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis]; COG0768" /db_xref="CDD:440531" ORIGIN 1 mssqrrnyrf ilvvtlfvla slavsgrlvy lqvhdhefla dqgdlrsird lpipvtrgmi 61 tdrngeplav stevasiwcn premaahlde vprlagalhr paaallaqlq anpnkrflyl 121 erglspieas evmalgitgv hqikeykrfy psseltaqli glvnidgrgq egtelgfndw 181 lsgkdgvrev ainprgslvn sikvlktpka sqdvalsidl rlqfiaykal ekavlkfgah 241 sgsavlvnpk sgqilamanf psynpnnras fapafmrnrt ltdtfepgsv ikpfsmsaal 301 asgkfdensq vsvapgwmti dghtihdvar rdvltmtgvl inssnigmsk valqigpkpi 361 leqlgrvgfg aplslgfpge npgylpfhek wsniatasms fgyslavnta elaqaysvfa 421 ndgklvplsl lrdnpqnqvr qamdpqiarr iramlqtvve dpkgvvrarv pgyhvagksg 481 tarkasgrgy adksyrslfv gmapasdpql vlavmidspt rigyfgglvs aptfsdimag 541 slralaippd nlqdspavad rqhhg