MULTISPECIES: 2-hydroxyacid dehydrogenase [Pseudomonas].

LOCUS       WP_003113741             328 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_003113741
VERSION     WP_003113741.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10143103
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..328
                     /product="2-hydroxyacid dehydrogenase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /calculated_mol_wt=35484
     Region          2..310
                     /region_name="GDH"
                     /note="D-glycerate dehydrogenase/hydroxypyruvate reductase
                     (GDH); cd05301"
                     /db_xref="CDD:240626"
     Site            order(8..9,11,51..52,72,100..101,104..105,107..108,111,
                     115,117,125,127,129,132..138,139..143,161..162,166..167,
                     265..266,274,280..286,288..291,293)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:240626"
     Site            order(51,73..75,98,236,284,287)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:240626"
     Site            order(74..75,102,151..155,174..176,179,206..208,212..213,
                     234..236,260..261,284,286..287)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:240626"
ORIGIN      
        1 mkkvvlykrl saplmerlre rvevllveep grdglarlrd alpeahgllg aslrldagll
       61 dlaprleaia svsvgvdnyd idyldrrgil lsntpdvlte ttadtgfali latarrvvel
      121 agwvragewk ksvgaaqfgt dvhgktlgiv gmgrigeala rrghhgfgmr vlyhshspkp
      181 hveeryaasy rpldallees dfvcltlplt aategligaa qfarmrpqai finisrgrvv
      241 deaalieala qrriraagld vfereplspd spllrlpnvv atphigsate etreamarca
      301 vdnllaalag arplnlvnps awarrrga