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LOCUS WP_003113558 685 aa linear BCT 24-DEC-2024 cyclase/phosphodiesterase [Pseudomonas]. ACCESSION WP_003113558 VERSION WP_003113558.1 KEYWORDS RefSeq. SOURCE Pseudomonas ORGANISM Pseudomonas Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae. REFERENCE 1 (residues 1 to 685) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 685) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 685) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 685) AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V. TITLE Novel domains of the prokaryotic two-component signal transduction systems JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001) PUBMED 11557134 REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4] COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11472025 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..685 /organism="Pseudomonas" /db_xref="taxon:286" Protein 1..685 /product="putative bifunctional diguanylate cyclase/phosphodiesterase" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /GO_function="GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity [Evidence IEA]" /calculated_mol_wt=74248 Region 6..682 /region_name="COG5001" /note="Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]" /db_xref="CDD:444025" ORIGIN 1 mlissynqvl vafslivail asytaldmag rvtlakgrea lswliggafa mgfgiwsmhf 61 vgmlafslpi plgydlgltl lslllavgss afalwlvcqa elpwqrlalg allmgsgiaa 121 mhytgmaall mmpgivydpl wlglsiliav iasgaalwia frlrhgsrri vlvragaalv 181 mgcaivgmhy tgmaaaqfpl gsfcgaagrg idngwlavlv ivitlaviai alivsvldsr 241 leartsvlat slaranreli qlalhdnltk lpnrmllddr leqaiqqair ddrrfavlfm 301 dldgfkavnd ayghhlgdll lievaerira nvraqdtiar lggdefvlli earepadaat 361 laeklvkris qpyqisrhev risasigial ypgdgqtrhe lminadaamy hakdqgrngy 421 cffessmnan aqeqlqllhd lrqalerrql vlhyqpkvla pngpmigvea llrwehpqhg 481 litpgqflpl aektglivqi gewvldeacr qmrlwldggh adwniavnls alqfahaglv 541 dsvrnallrh slepshlile vtestamrda daslvileql samgvgisid dfgtgyssll 601 ylkrlpasel kidrgfinel ahdsddaaiv saivalgrtl nlkivaegve teaqqefltr 661 lgcnslqgfl lgrpmpaeql lasva