MULTISPECIES: putative bifunctional diguanylate

LOCUS       WP_003113344             587 aa            linear   BCT 23-DEC-2024
            cyclase/phosphodiesterase [Pseudomonas].
ACCESSION   WP_003113344
VERSION     WP_003113344.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 587)
  AUTHORS   Romling,U. and Amikam,D.
  TITLE     Cyclic di-GMP as a second messenger
  JOURNAL   Curr Opin Microbiol 9 (2), 218-228 (2006)
   PUBMED   16530465
REFERENCE   2  (residues 1 to 587)
  AUTHORS   Romling,U., Gomelsky,M. and Galperin,M.Y.
  TITLE     C-di-GMP: the dawning of a novel bacterial signalling system
  JOURNAL   Mol Microbiol 57 (3), 629-639 (2005)
   PUBMED   16045609
REFERENCE   3  (residues 1 to 587)
  AUTHORS   Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U.
  TITLE     GGDEF and EAL domains inversely regulate cyclic di-GMP levels and
            transition from sessility to motility
  JOURNAL   Mol Microbiol 53 (4), 1123-1134 (2004)
   PUBMED   15306016
REFERENCE   4  (residues 1 to 587)
  AUTHORS   Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V.
  TITLE     Novel domains of the prokaryotic two-component signal transduction
            systems
  JOURNAL   FEMS Microbiol Lett 203 (1), 11-21 (2001)
   PUBMED   11557134
  REMARK    Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4]
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11472025
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..587
                     /product="putative bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071111 - cyclic-guanylate-specific
                     phosphodiesterase activity [Evidence IEA]"
                     /calculated_mol_wt=65487
     Region          1..587
                     /region_name="COG5001"
                     /note="Cyclic di-GMP metabolism protein, combines GGDEF
                     and EAL domains with a 6TM membrane domain [Signal
                     transduction mechanisms]"
                     /db_xref="CDD:444025"
ORIGIN      
        1 matppypede hsrqayvdql glleegadev feeilaaats yfqtpialis ildhqrqwfr
       61 asigldirqt prrdsfcaya ilgkgvfeva datldprfrd npyvqgepri rfyagaplat
      121 aeglnlgslc vidreprgpl aerdvamleh farlvmarih tlrstnyide ptglynrlrl
      181 qedvslrlqr dgaltviaad llplallnti irtlgypfsn dlmleardri raelpdftly
      241 kisptrfgll lprqqqeete svclrllraf espvvcrgip ikanvglgvl pladdtldgd
      301 qdwlrlvvsa addardrgvg warynppldq aqqraftllt slsqaigtee gfhlvyqpki
      361 dlptgrctgv eallrwrhpq lgfvspaefv plaektalmr plsdwvlrha maqlaqwnar
      421 niplrlainv sasdmedssf leeavrlakt ydidlsalel eftesvlird asavgsvllr
      481 arelgmgiav ddfgtgysnw tylrdlpita ikldqsftrd lagspkaqsv tqaviglasq
      541 lgyrvvaegi ethdtfhllq awgchegqgy liaqpmlpeq ledwlrr