MULTISPECIES: aldo/keto reductase [Pseudomonas].

LOCUS       WP_003113326             331 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_003113326
VERSION     WP_003113326.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Penning,T.M.
  TITLE     The aldo-keto reductases (AKRs): Overview
  JOURNAL   Chem Biol Interact 234, 236-246 (2015)
   PUBMED   25304492
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Mindnich,R.D. and Penning,T.M.
  TITLE     Aldo-keto reductase (AKR) superfamily: genomics and annotation
  JOURNAL   Hum Genomics 3 (4), 362-370 (2009)
   PUBMED   19706366
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Sanli,G., Dudley,J.I. and Blaber,M.
  TITLE     Structural biology of the aldo-keto reductase family of enzymes:
            catalysis and cofactor binding
  JOURNAL   Cell Biochem Biophys 38 (1), 79-101 (2003)
   PUBMED   12663943
REFERENCE   4  (residues 1 to 331)
  AUTHORS   Jez,J.M., Bennett,M.J., Schlegel,B.P., Lewis,M. and Penning,T.M.
  TITLE     Comparative anatomy of the aldo-keto reductase superfamily
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 625-636 (1997)
   PUBMED   9307009
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 14442355
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..331
                     /product="aldo/keto reductase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /calculated_mol_wt=36131
     Region          2..307
                     /region_name="AKR_AKR13A_13D"
                     /note="AKR13A and AKR13D families of aldo-keto reductase
                     (AKR); cd19076"
                     /db_xref="CDD:381302"
     Site            order(21,206..209,212,262,280..284,287,290..291)
                     /site_type="active"
                     /db_xref="CDD:381302"
     Site            order(52,57,82,126)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381302"
ORIGIN      
        1 mktrqlghng psvsaiglgc mgmtdfyttg gdrqeaiatl hravelglnf fdtadmygph
       61 sneellgeal rgkreqvfla skfgivrdpa nprargvdgs payirraieg slkrlgtdrl
      121 dlyyqhrmdp qvpiedsvga ladlvkagki rhiglseasa etlerahrvh pisalqseys
      181 lwtrdpedtg vlaacrrlgi afvpysplgr gfltgtlkrp edfaaddyrr fsprfqgenf
      241 aknlklvdkv gelaaakgvk psqlalawvl aqgddlipip gtkqrrylee nvaatelrls
      301 aaelaeldai fpaeavagsr yseegmrlvn l