oxidoreductase MexS [Pseudomonas aeruginosa].

LOCUS       WP_003113302             339 aa            linear   BCT 10-JUL-2019
ACCESSION   WP_003113302
VERSION     WP_003113302.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 339)
  AUTHORS   Richardot,C., Juarez,P., Jeannot,K., Patry,I., Plesiat,P. and
            Llanes,C.
  TITLE     Amino Acid Substitutions Account for Most MexS Alterations in
            Clinical nfxC Mutants of Pseudomonas aeruginosa
  JOURNAL   Antimicrob. Agents Chemother. 60 (4), 2302-2310 (2016)
   PUBMED   26833155
REFERENCE   2  (residues 1 to 339)
  AUTHORS   Uwate,M., Ichise,Y.K., Shirai,A., Omasa,T., Nakae,T. and Maseda,H.
  TITLE     Two routes of MexS-MexT-mediated regulation of MexEF-OprN and
            MexAB-OprM efflux pump expression in Pseudomonas aeruginosa
  JOURNAL   Microbiol. Immunol. 57 (4), 263-272 (2013)
   PUBMED   23586630
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006436
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..339
                     /gene="mexS"
     Protein         1..339
                     /product="oxidoreductase MexS"
                     /calculated_mol_wt=36701
     Region          2..337
                     /region_name="MDR2"
                     /note="Medium chain dehydrogenases/reductase
                     (MDR)/zinc-dependent alcohol dehydrogenase-like family;
                     cd08268"
                     /db_xref="CDD:176229"
     Site            order(41..43,46,122,132,153..156,158..159,177..178,182,
                     197,221..222,224,243..244,268..270)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:176229"
ORIGIN      
        1 msrvirfhqf gppevlkcee lptpapaage vlvrvqaigv swkdvlwrqn lapeqaalps
       61 glgfelagev lavgagvgdl plgsrvasfp ahtpdhypay gdvvlmpraa lavypevltp
      121 veasvyytgl lvayfglvdl aglkagqtvl iteaarmygp vsiqlakalg arviastksa
      181 eereflreqg adkvvvtdeq dlvleverft egkgvnvild elggpqmtll gdvsatrgkl
      241 vlygcnggde safpacaafk khlqfyrhcl mdftghpemg lerndesvsk alahieqltr
      301 drllkpvvdr vfefdqvvea hrymetcpkr grvvihvad