EAL domain-containing protein [Pseudomonas aeruginosa].

LOCUS       WP_003113216            1245 aa            linear   BCT 26-FEB-2025
ACCESSION   WP_003113216
VERSION     WP_003113216.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 1245)
  AUTHORS   Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V.
  TITLE     Novel domains of the prokaryotic two-component signal transduction
            systems
  JOURNAL   FEMS Microbiol Lett 203 (1), 11-21 (2001)
   PUBMED   11557134
  REMARK    Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4]
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF012772.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF00563.25
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..1245
                     /product="EAL domain-containing protein"
                     /calculated_mol_wt=139530
     Region          36..255
                     /region_name="PBP2_BvgS_HisK_like"
                     /note="The type 2 periplasmic ligand-binding protein
                     domain of the sensor-kinase BvgS and histidine kinase
                     receptors, and related proteins; cd01007"
                     /db_xref="CDD:270228"
     Region          310..432
                     /region_name="PAS"
                     /note="PAS domain; PAS motifs appear in archaea,
                     eubacteria and eukarya. Probably the most surprising
                     identification of a PAS domain was that in EAG-like
                     K+-channels. PAS domains have been found to bind ligands,
                     and to act as sensors for light and oxygen in...; cl21578"
                     /db_xref="CDD:473914"
     Site            order(338,342,348,361,363..365,391,396)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(358,363,371,374..375,403,405)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          430..682
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          565..1236
                     /region_name="COG5001"
                     /note="Cyclic di-GMP metabolism protein, combines GGDEF
                     and EAL domains with a 6TM membrane domain [Signal
                     transduction mechanisms]"
                     /db_xref="CDD:444025"
ORIGIN      
        1 mqrlqavlll claccwpgla galtltpeer awlaehpsir lgmdtswppf eyrdeqgryq
       61 glaagyigll qerlsvsltp vepktwtqvl eqakdgrldl lpgimatper qeylsftrpy
      121 ldfpiiilar kngpmpkrid elyglkvavv dhyaphelli aqhpdltllp lpsvaaalqa
      181 latgqadafv gdfassvwnl rqlklnglei sgetpyryql amavprgqpi lagivdkvla
      241 dlsageierl qapwvgglld rrpawremat yglpivllil vsvaillamn rrlrrevsrr
      301 rqlerelrds eqhyrglves lnaiawemrl eenrftyvsp haerllgypl gewlqpgfwq
      361 rtlhpmdaey aihycmsesq agrdhsfdyr mlaadgrvvw irdlvtpitq grdlllrglm
      421 iditeaklte qamrlseqkf asvfhhcpdm vvlangadgr flavnstfeq qigiaaddai
      481 gktatelgiw alpglgpqvl eklghgnltn levplrrrng stfsallsaq hvaldqtpal
      541 vvvirdithl vetqellris eekfanafha ypdgllissl edgtlidvne gftrltgyrr
      601 devisrstle lglwvdtedr krlislvrhh tltqgftapv rdrnggirqc emsahrisid
      661 gedcvltiar diterqlmqe klqqaatvfe staegvmitd trqritavnr afseitgyse
      721 qealgrspsl lssgqhdssf ylamwnqler dghwqgeiwn rrktgelype wltisavhnp
      781 qgeithfvgv fadistlkya qarldyqahh dpltglpnrl lfesrlnhal deareesrpg
      841 avlfidldrf khindslghp igdlllkaia erlrdqlrdv dtvarlggde fiillpglhq
      901 esdaehvark llnaftapfq adgheffvsa svgialfpkd gddaptlvkn adaamyraks
      961 rgrsrieyyt reltylater maletelrra lerdelqlyy qpklslesgl lvgaealvrw
     1021 yhplfgeisp erfiplaedc glilplgdwv lehacqqmge wqklhapfgp lsvnlagaql
     1081 gqpqlierle qlleqsglep srlqleites fimnqteeal avlhglkrlg vqlaiddfgt
     1141 gysslsylkr lpldilkidk sfirglpddp hdaaitraii algrsmqltv iaegvetegq
     1201 qsflthegce qiqgfvlspp lpaelfaskf lkprqpigap reapv