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PAS domain-containing sensor histidine kinase [Pseudomonas


LOCUS       WP_003113207             797 aa            linear   BCT 25-FEB-2025
            aeruginosa].
ACCESSION   WP_003113207
VERSION     WP_003113207.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 797)
  AUTHORS   Stuffle,E.C., Johnson,M.S. and Watts,K.J.
  TITLE     PAS domains in bacterial signal transduction
  JOURNAL   Curr Opin Microbiol 61, 8-15 (2021)
   PUBMED   33647528
REFERENCE   2  (residues 1 to 797)
  AUTHORS   Ortet,P., Whitworth,D.E., Santaella,C., Achouak,W. and Barakat,M.
  TITLE     P2CS: updates of the prokaryotic two-component systems database
  JOURNAL   Nucleic Acids Res 43 (Database issue), D536-D541 (2015)
   PUBMED   25324303
REFERENCE   3  (residues 1 to 797)
  AUTHORS   Dwyer,M.A. and Hellinga,H.W.
  TITLE     Periplasmic binding proteins: a versatile superfamily for protein
            engineering
  JOURNAL   Curr Opin Struct Biol 14 (4), 495-504 (2004)
   PUBMED   15313245
REFERENCE   4  (residues 1 to 797)
  AUTHORS   Hefti,M.H., Francoijs,K.J., de Vries,S.C., Dixon,R. and Vervoort,J.
  TITLE     The PAS fold. A redefinition of the PAS domain based upon
            structural prediction
  JOURNAL   Eur J Biochem 271 (6), 1198-1208 (2004)
   PUBMED   15009198
REFERENCE   5  (residues 1 to 797)
  AUTHORS   Dutta,R. and Inouye,M.
  TITLE     GHKL, an emergent ATPase/kinase superfamily
  JOURNAL   Trends Biochem Sci 25 (1), 24-28 (2000)
   PUBMED   10637609
REFERENCE   6  (residues 1 to 797)
  AUTHORS   Stock,A.M., Robinson,V.L. and Goudreau,P.N.
  TITLE     Two-component signal transduction
  JOURNAL   Annu Rev Biochem 69, 183-215 (2000)
   PUBMED   10966457
REFERENCE   7  (residues 1 to 797)
  AUTHORS   Stock,J.
  TITLE     Signal transduction: Gyrating protein kinases
  JOURNAL   Curr Biol 9 (10), R364-R367 (1999)
   PUBMED   10339418
REFERENCE   8  (residues 1 to 797)
  AUTHORS   Felder,C.B., Graul,R.C., Lee,A.Y., Merkle,H.P. and Sadee,W.
  TITLE     The Venus flytrap of periplasmic binding proteins: an ancient
            protein module present in multiple drug receptors
  JOURNAL   AAPS PharmSci 1 (2), E2 (1999)
   PUBMED   11741199
REFERENCE   9  (residues 1 to 797)
  AUTHORS   Ponting,C.P. and Aravind,L.
  TITLE     PAS: a multifunctional domain family comes to light
  JOURNAL   Curr Biol 7 (11), R674-R677 (1997)
   PUBMED   9382818
REFERENCE   10 (residues 1 to 797)
  AUTHORS   Alex,L.A. and Simon,M.I.
  TITLE     Protein histidine kinases and signal transduction in prokaryotes
            and eukaryotes
  JOURNAL   Trends Genet 10 (4), 133-138 (1994)
   PUBMED   8029829
REFERENCE   11 (residues 1 to 797)
  AUTHORS   Tam,R. and Saier,M.H. Jr.
  TITLE     Structural, functional, and evolutionary relationships among
            extracellular solute-binding receptors of bacteria
  JOURNAL   Microbiol Rev 57 (2), 320-346 (1993)
   PUBMED   8336670
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11541443
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..797
                     /product="PAS domain-containing sensor histidine kinase"
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /calculated_mol_wt=89386
     Region          39..259
                     /region_name="PBP2_BvgS_HisK_like"
                     /note="The type 2 periplasmic ligand-binding protein
                     domain of the sensor-kinase BvgS and histidine kinase
                     receptors, and related proteins; cd01007"
                     /db_xref="CDD:270228"
     Region          313..575
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          579..793
                     /region_name="ComP"
                     /note="Signal transduction histidine kinase ComP [Signal
                     transduction mechanisms]; COG4585"
                     /db_xref="CDD:443642"
ORIGIN      
        1 mlrrccllff clllslpvra eesvalplta elrtwlaehr elrvgvvtea pyaqydrrlq
       61 qysganvelm gwlatamqvt lrwqgypdqa alddalragr vdiapglsqt paglrlwlfs
      121 dpylrvsrlv vgkrdgsgsv eleqlerdtr vavragssva dylsstysgl qwvsadsere
      181 vlravlagqa ryavideaql srltrepefa elavvgdigy pqllrvatrr dwpelamvvd
      241 qalrslprks ldqlherwlq pkyprlgesp gfwqnlsill glllagalva vflqrrqqha
      301 learlygarr dlelrqaaee alrltqfsid nstlgilwvn wdsrvryanr aaeqmlghad
      361 gqlvdrplad fepgldmdrw lnlwrrarns eegplsfetr clradgswlp advslsflrf
      421 gtseylvvfl sdvterrrar ealqesearm kgiasnvpgm vfrlerprag afsdfayise
      481 gsealvgysa reliesgrgi rglvhpddre rywssqmaal denrdwhwqg riltrqgelr
      541 wadikasarc fedgravwdg vvwditankq ielelgesra qlrelsahle svreeekari
      601 arevhdelgq vltvlklets mcelayadaq eglrerlgnm kkliaqlfql vrdvatalrp
      661 pildagigsa vewqarrfea rtqipclvev penspqlvda kaiglfrilq ealtnvmrha
      721 eahtvqlrll regdelclsv sddgrgfdva tvgrgssfgl vgmrervlmm ggtldidsap
      781 gegttlsvri plgvagp