MFS transporter [Pseudomonas aeruginosa].

LOCUS       WP_003113161             391 aa            linear   BCT 28-JUL-2024
ACCESSION   WP_003113161
VERSION     WP_003113161.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 391)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 391)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023516
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..391
                     /product="MFS transporter"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=40645
     Region          11..334
                     /region_name="MFS_NepI_like"
                     /note="Purine ribonucleoside efflux pump NepI and similar
                     transporters of the Major Facilitator Superfamily;
                     cd17324"
                     /db_xref="CDD:340882"
     Site            order(15..16,19..20,23,55,105..106,108..110,113,133,
                     136..137,140,208,211..212,215..217,220,249,253,302..303,
                     307,311,326,329..330,333..334)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340882"
ORIGIN      
        1 mdlrllllsl ttfaaglaes iligilppla edlrvsisla gqlttlfslg falaapllgw
       61 ltrrierrrl llatlllfal snalaalapg ylglllarlg msaccglliv lasllaaela
      121 apaqrgraig lifmgisgsl vfgvplgvqi sdwfgwrwif agiavyslpl clllwrylpq
      181 rqagdlpgre gylrqlrqpa lwlaqlvsil llgghftlfa yftpylasma girspseisl
      241 illliglaal sggyiggwla dhlghrralr lvpaafalal aavplslgsi gflpvlmvws
      301 aiswmispvv qsfllrsdpa sgsagvalnt samhlgvglg aalgglvvaa lgvaatpwvg
      361 lalvlaalac algastldga tqalpfsppa r