M24 family metallopeptidase [Pseudomonas aeruginosa].

LOCUS       WP_003113146             291 aa            linear   BCT 19-MAR-2023
ACCESSION   WP_003113146
VERSION     WP_003113146.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 291)
  AUTHORS   Lowther,W.T. and Matthews,B.W.
  TITLE     Metalloaminopeptidases: common functional themes in disparate
            structural surroundings
  JOURNAL   Chem Rev 102 (12), 4581-4608 (2002)
   PUBMED   12475202
REFERENCE   2  (residues 1 to 291)
  AUTHORS   Rawlings,N.D. and Barrett,A.J.
  TITLE     Evolutionary families of metallopeptidases
  JOURNAL   Methods Enzymol 248, 183-228 (1995)
   PUBMED   7674922
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10099437
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..291
                     /product="M24 family metallopeptidase"
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /calculated_mol_wt=32836
     Region          13..263
                     /region_name="APP_MetAP"
                     /note="A family including aminopeptidase P, aminopeptidase
                     M, and prolidase. Also known as metallopeptidase family
                     M24. This family of enzymes is able to cleave amido-,
                     imido- and amidino-containing bonds. Members exibit
                     relatively narrow substrate specificity...; cd01066"
                     /db_xref="CDD:238514"
     Site            order(88,105,116,194,242,255)
                     /site_type="active"
                     /db_xref="CDD:238514"
ORIGIN      
        1 msqgawvptp ddldhfrqvq rlaytcceti hgelrpgise reaaalmktw lqdhgvddwf
       61 hqpfawfgsr tsfkgfdglr hlggfnlafy pgkqrleegm pfildcaptl gaytadvgys
      121 galghnllqe rlmddllihr rtildlvrer rplaevsqav drlcviqgtl prhkaypfev
      181 lahrveklgn rrgpsvarfg vrnlytltrn alvtgkregw splwssgkrs ehpptsglwa
      241 vephlglrgv gakfeellvv teddaywldd dlphvrrwqa rgllpqarea a