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MULTISPECIES: protease modulator HflK [Pseudomonas].


LOCUS       WP_003113078             666 aa            linear   BCT 24-JUL-2024
ACCESSION   WP_003113078
VERSION     WP_003113078.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 666)
  AUTHORS   Bandyopadhyay,K., Parua,P.K., Datta,A.B. and Parrack,P.
  TITLE     Studies on Escherichia coli HflKC suggest the presence of an
            unidentified lambda factor that influences the lysis-lysogeny
            switch
  JOURNAL   BMC Microbiol 11, 34 (2011)
   PUBMED   21324212
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 666)
  AUTHORS   Bandyopadhyay,K., Parua,P.K., Datta,A.B. and Parrack,P.
  TITLE     Escherichia coli HflK and HflC can individually inhibit the HflB
            (FtsH)-mediated proteolysis of lambdaCII in vitro
  JOURNAL   Arch Biochem Biophys 501 (2), 239-243 (2010)
   PUBMED   20599668
REFERENCE   3  (residues 1 to 666)
  AUTHORS   Browman,D.T., Hoegg,M.B. and Robbins,S.M.
  TITLE     The SPFH domain-containing proteins: more than lipid raft markers
  JOURNAL   Trends Cell Biol 17 (8), 394-402 (2007)
   PUBMED   17766116
REFERENCE   4  (residues 1 to 666)
  AUTHORS   Briere,L.K. and Dunn,S.D.
  TITLE     The periplasmic domains of Escherichia coli HflKC oligomerize
            through right-handed coiled-coil interactions
  JOURNAL   Biochemistry 45 (28), 8607-8616 (2006)
   PUBMED   16834335
REFERENCE   5  (residues 1 to 666)
  AUTHORS   Tavernarakis,N., Driscoll,M. and Kyrpides,N.C.
  TITLE     The SPFH domain: implicated in regulating targeted protein turnover
            in stomatins and other membrane-associated proteins
  JOURNAL   Trends Biochem Sci 24 (11), 425-427 (1999)
   PUBMED   10542406
REFERENCE   6  (residues 1 to 666)
  AUTHORS   Kihara,A., Akiyama,Y. and Ito,K.
  TITLE     Host regulation of lysogenic decision in bacteriophage lambda:
            transmembrane modulation of FtsH (HflB), the cII degrading
            protease, by HflKC (HflA)
  JOURNAL   Proc Natl Acad Sci U S A 94 (11), 5544-5549 (1997)
   PUBMED   9159109
REFERENCE   7  (residues 1 to 666)
  AUTHORS   Kihara,A., Akiyama,Y. and Ito,K.
  TITLE     A protease complex in the Escherichia coli plasma membrane: HflKC
            (HflA) forms a complex with FtsH (HflB), regulating its proteolytic
            activity against SecY
  JOURNAL   EMBO J 15 (22), 6122-6131 (1996)
   PUBMED   8947034
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10130454
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..666
                     /gene="hflK"
     Protein         1..666
                     /product="protease modulator HflK"
                     /GO_component="GO:0098797 - plasma membrane protein
                     complex [Evidence IEA]"
                     /GO_process="GO:0052547 - regulation of peptidase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=70402
     Region          318..621
                     /region_name="SPFH_HflK"
                     /note="High frequency of lysogenization K (HflK) family;
                     SPFH (stomatin, prohibitin, flotillin, and HflK/C)
                     superfamily; cd03404"
                     /db_xref="CDD:259802"
ORIGIN      
        1 mrvdldaegv aaeslprfqq aprqlrqlwr waaasvalaa acavlgffig lfaadslwpp
       61 llynlgaawl vlfaglhaay rvaawrcvvl gaeasarpaw lrwqrdepda tadsayerll
      121 erlgqaiahg laqlghaalw laasaalalc lvaagwrldl ppassgqaad laigicllla
      181 favlvlerrl asqgpaqwpe apvlgqlara ligtlvlaal clflarqghp waprlavllg
      241 llpaalalel lgrailamfa pqragleprl vatslladll rwpprplqrl qhelhqrfgi
      301 dlrqvwafgf mrraflpvla vvslsgwlls gvreigmdar gvyerfgkpv avlgpglhlg
      361 lpwplgrvla vengvvhela tsvaagdgga eplapaegpa pdsanrlwda shvseksqvi
      421 asladhrqsf qivnmdvriv yrialddasa laatyrsadv ptlvrstasr vlvhafasrt
      481 ldevlgeqra glaeqigqav qadldrlgsg vevlgaavea ihppagaana yhavqaaqit
      541 aqaliarerg qaaaqrneaq lqasvahdra saqaretlaa aqaadrrfaa eregyadagq
      601 aflleayyrq lgrglgkanl llidhriaga gaptidlrsf glgrldspss srpsaapasa
      661 agqsap