MULTISPECIES: bifunctional

LOCUS       WP_003113051             373 aa            linear   BCT 22-AUG-2022
            diaminohydroxyphosphoribosylaminopyrimidine
            deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
            [Pseudomonas].
ACCESSION   WP_003113051
VERSION     WP_003113051.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00326.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..373
                     /gene="ribD"
     Protein         1..373
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008835 -
                     diaminohydroxyphosphoribosylaminopyrimidine deaminase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=39634
     Region          5..373
                     /region_name="DHFR"
                     /note="Dihydrofolate reductase (DHFR). Reduces
                     7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH
                     as a cofactor. This is an essential step in the
                     biosynthesis of deoxythymidine phosphate since
                     5,6,7,8-tetrahydrofolate is required to regenerate 5;
                     cl17279"
                     /db_xref="CDD:473077"
ORIGIN      
        1 mnaadplyma ralelarqgl ystqpnprvg cvlvkdgqvv gegwhvrage phaevhalrq
       61 agenargata yvtlepcshf grtppcadal vgagvarvva amqdpnpeva grgllrlmqa
      121 giavqsgvle aearelnigf ikrmehglpf vrvklamsld grtamasges qwitgpsars
      181 avqrlrarss vvlsgadtll addarlnvrp delglnaelt alaaarqplr vlvdgrlrvp
      241 lesafyqagp alvatcaaas arerfqdagh ellalpsaeg hvdlhkllle laarganevl
      301 veagprlaga farlglvdey rlfvapkflg ssarplldwp larmadaaql riddiravgd
      361 dwlvtarphl rda