MULTISPECIES: thiamine pyrophosphate-dependent dehydrogenase E1

LOCUS       WP_003112998             324 aa            linear   BCT 31-DEC-2024
            component subunit alpha [Pseudomonas].
ACCESSION   WP_003112998
VERSION     WP_003112998.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 324)
  AUTHORS   Frank,R.A., Titman,C.M., Pratap,J.V., Luisi,B.F. and Perham,R.N.
  TITLE     A molecular switch and proton wire synchronize the active sites in
            thiamine enzymes
  JOURNAL   Science 306 (5697), 872-876 (2004)
   PUBMED   15514159
REFERENCE   2  (residues 1 to 324)
  AUTHORS   Jordan,F.
  TITLE     Current mechanistic understanding of thiamin diphosphate-dependent
            enzymatic reactions
  JOURNAL   Nat Prod Rep 20 (2), 184-201 (2003)
   PUBMED   12735696
REFERENCE   3  (residues 1 to 324)
  AUTHORS   Hawkins,C.F., Borges,A. and Perham,R.N.
  TITLE     A common structural motif in thiamin pyrophosphate-binding enzymes
  JOURNAL   FEBS Lett 255 (1), 77-82 (1989)
   PUBMED   2792374
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10787196
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..324
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /EC_number="1.2.4.-"
                     /GO_function="GO:0016624 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, disulfide as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /calculated_mol_wt=34457
     Region          4..324
                     /region_name="AcoA"
                     /note="TPP-dependent pyruvate or acetoin dehydrogenase
                     subunit alpha [Energy production and conversion]; COG1071"
                     /db_xref="CDD:440689"
ORIGIN      
        1 mstlstdqll hayrvmrtir afeerlhvef atgeipgfvh lyageeasaa gvmahlrddd
       61 ciasthrghg hciakgvdvh gmmaeiygkk tgvcqgkggs mhiadlekgm lgangivgag
      121 aplaagaala aklkgsdava vaffgdggsn egavfeamnl asvwnlpclf vaenngyaea
      181 taanwsvacd hiadraagfg mpgvtvdgfd ffavheaaga aierarageg pslievkltr
      241 yyghfegdaq tyrdpdevkh yretrdclkq frertchagl lsasdldaid aevearieda
      301 vqrakndpkp epddllrdvy vsyp