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LOCUS WP_003112959 423 aa linear BCT 31-DEC-2024 ACCESSION WP_003112959 VERSION WP_003112959.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 423) AUTHORS Kallberg,Y., Oppermann,U. and Persson,B. TITLE Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models JOURNAL FEBS J 277 (10), 2375-2386 (2010) PUBMED 20423462 REFERENCE 2 (residues 1 to 423) AUTHORS Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L., Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N., Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M., Thornton,J.M., Adamski,J. and Oppermann,U. TITLE The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative JOURNAL Chem Biol Interact 178 (1-3), 94-98 (2009) PUBMED 19027726 REFERENCE 3 (residues 1 to 423) AUTHORS Kavanagh,K.L., Jornvall,H., Persson,B. and Oppermann,U. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes JOURNAL Cell Mol Life Sci 65 (24), 3895-3906 (2008) PUBMED 19011750 REFERENCE 4 (residues 1 to 423) AUTHORS Ladenstein,R., Winberg,J.O. and Benach,J. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : Structure-function relationships in short-chain alcohol dehydrogenases JOURNAL Cell Mol Life Sci 65 (24), 3918-3935 (2008) PUBMED 19011748 REFERENCE 5 (residues 1 to 423) AUTHORS Oppermann,U., Filling,C., Hult,M., Shafqat,N., Wu,X., Lindh,M., Shafqat,J., Nordling,E., Kallberg,Y., Persson,B. and Jornvall,H. TITLE Short-chain dehydrogenases/reductases (SDR): the 2002 update JOURNAL Chem Biol Interact 143-144, 247-253 (2003) PUBMED 12604210 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10396284 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..423 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..423 /product="SDR family oxidoreductase" /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0051287 - NAD binding [Evidence IEA]" /calculated_mol_wt=45180 Region 1..264 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(7,9..10,12,31..33,71..73,107..109,120,124,143..146) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187535" Site order(86,109,120,124) /site_type="active" /db_xref="CDD:187535" Region 307..408 /region_name="DoxX_3" /note="DoxX-like family; pfam13781" /db_xref="CDD:463982" ORIGIN 1 mrillvgagg fvgrhllpal laaghelllt arrppvdapa gvrwlaldle rlaerpdsfa 61 wpagvdllin aagtmsldea smarvqdsga rtlfdlaaah gakvlqisal gagahpdvaf 121 laskaaadrh llelgipalv lrpslllgpg gassawlerl splpliplld nrarlqplhv 181 edlvgavlal lrcwperaqv iplvgpqalt qgelldelrr aqgwprgryv vppaalldal 241 gglgrragwr tlspsmlklv rhdnladpal ldeacgyrca plasrllgwp qaarslaalm 301 rplmlaalvl iwlgtlvacl gpgygwglri lgeagihgwp aslaviagal ldgalgvgll 361 lrrwrrrall aqfwlmlgys laislilphy wydpymavgk nivlmvatlw llgdeprtre 421 arg