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isoleucine--tRNA ligase [Pseudomonas aeruginosa].


LOCUS       WP_003112822             943 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_003112822
VERSION     WP_003112822.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 943)
  AUTHORS   Fukunaga,R. and Yokoyama,S.
  TITLE     Crystallization and preliminary X-ray crystallographic study of the
            editing domain of Thermus thermophilus isoleucyl-tRNA synthetase
            complexed with pre- and post-transfer editing-substrate analogues
  JOURNAL   Acta Crystallogr D Biol Crystallogr 60 (Pt 10), 1900-1902 (2004)
   PUBMED   15388946
REFERENCE   2  (residues 1 to 943)
  AUTHORS   Yanagisawa,T. and Kawakami,M.
  TITLE     How does Pseudomonas fluorescens avoid suicide from its antibiotic
            pseudomonic acid?: Evidence for two evolutionarily distinct
            isoleucyl-tRNA synthetases conferring self-defense
  JOURNAL   J Biol Chem 278 (28), 25887-25894 (2003)
   PUBMED   12672810
REFERENCE   3  (residues 1 to 943)
  AUTHORS   Nakama,T., Nureki,O. and Yokoyama,S.
  TITLE     Structural basis for the recognition of isoleucyl-adenylate and an
            antibiotic, mupirocin, by isoleucyl-tRNA synthetase
  JOURNAL   J Biol Chem 276 (50), 47387-47393 (2001)
   PUBMED   11584022
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00392.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..943
                     /gene="ileS"
     Protein         1..943
                     /product="isoleucine--tRNA ligase"
                     /EC_number="6.1.1.5"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004822 - isoleucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006428 - isoleucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=105334
     Region          4..935
                     /region_name="IleS"
                     /note="Isoleucyl-tRNA synthetase [Translation, ribosomal
                     structure and biogenesis]; COG0060"
                     /db_xref="CDD:439830"
ORIGIN      
        1 mtdykatlnl petafpmkag lpqrepetlk fwndiglyqk lraiggdrpk fvlhdgppya
       61 ngsihighav nkilkdiivr sktlagydap yvpgwdchgl piehkvetth gknlpadktr
      121 elcreyaaeq iegqkadfir lgvlgewdnp yktmnfanea neiralaemv kqdfvfkglk
      181 pvnwcfdcgs alaeaeveya dkksptidvg fpvadadkla aafglaaldk paqiviwttt
      241 pwtipanqal nvhpeidyal vdagdrylvl aealvescla ryqregkvva takgealeli
      301 nfrhpfyerl spvyladyva ldagtgivhs spaygeddfy tckrygmsnd dilspvqsng
      361 vyvdslpffg gqfiwkanpn vvakleevgs llahetinhs ymhcwrhktp liyrataqwf
      421 vgmdkqprqg aslreralea itqtefvpgw gqarlhgmia grpdwcisrq rnwgvpipff
      481 lhkasgelhp rtvelmeeva qrvekegiea wfkldaaell geeaaqyeki ndtldvwfds
      541 gtthwhvlrg shrighasgp vadlylegsd qhrgwfhssl ltgcaidnha pyrqllthgf
      601 tvdesgrkms kslgntvvpq tvidtlgadi lrlwvastdy sgeiavsqqi lqrsadayrr
      661 irnttrflls nlngfdpatd llppqemlal drwavdrall lqreieeayr eyrfwnvysk
      721 vhnfcvqelg gfyldiikdr qyttgansva rrscqtalfh iaealvrwia pilaftaeev
      781 wkflpgerae svmlatwydg lnelpadvtl nrqyweqvma vkaavnkele nqraakavgg
      841 nlqaevtlya edalqaqlak lgnelrfvli tstatlapls aapadavdse vaglklkvvk
      901 sthakcgrcw hhredvgqha ahpdlcgrci eniegsgevr hya