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LOCUS WP_003112701 318 aa linear BCT 19-FEB-2025 ACCESSION WP_003112701 VERSION WP_003112701.1 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa ORGANISM Pseudomonas aeruginosa Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 318) AUTHORS Toro,N. and Nisa-Martinez,R. TITLE Comprehensive phylogenetic analysis of bacterial reverse transcriptases JOURNAL PLoS One 9 (11), e114083 (2014) PUBMED 25423096 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 318) AUTHORS Simon,D.M. and Zimmerly,S. TITLE A diversity of uncharacterized reverse transcriptases in bacteria JOURNAL Nucleic Acids Res 36 (22), 7219-7229 (2008) PUBMED 19004871 REFERENCE 3 (residues 1 to 318) AUTHORS Inouye,S. and Inouye,M. TITLE Structure, function, and evolution of bacterial reverse transcriptase JOURNAL Virus Genes 11 (2-3), 81-94 (1995) PUBMED 8828137 REFERENCE 4 (residues 1 to 318) AUTHORS Xiong,Y. and Eickbush,T.H. TITLE Origin and evolution of retroelements based upon their reverse transcriptase sequences JOURNAL EMBO J 9 (10), 3353-3362 (1990) PUBMED 1698615 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10131200 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..318 /organism="Pseudomonas aeruginosa" /db_xref="taxon:287" Protein 1..318 /product="reverse transcriptase family protein" /EC_number="2.7.7.49" /GO_function="GO:0003723 - RNA binding [Evidence IEA]" /GO_function="GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0006974 - DNA damage response [Evidence IEA]" /calculated_mol_wt=36459 Region 40..255 /region_name="RT_Bac_retron_II" /note="Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a...; cd03487" /db_xref="CDD:239569" Site order(97..102,145..146,179,181..182,231..232) /site_type="active" /note="putative active site [active]" /db_xref="CDD:239569" Site order(97..102,145,181) /site_type="other" /note="putative NTP binding site [chemical binding]" /db_xref="CDD:239569" Site 146 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:239569" ORIGIN 1 mkkrpledlf famyrgkqsf ehfancsveg lyepvmvngr lvyktdkdlr ayhrflnkfl 61 ferlpvvddv vfsyrkgvna vdavekhags kfyfqtdlrd ffssltksdv rrtlewakdv 121 cvisdldvwv erilklvtig dslpmgfsts paisnaclys ldgilkthcl sngviytrya 181 ddlifsssnk qaldplfgvv crtlqsefsg rmginsqktk ylrkggkikl lglnvlpngr 241 vtvdmrhkke ievrlfyyvk drarflkimg evddekaikk fsglinyvnt vdpayldklr 301 kkygltivdm fihkspkl