MULTISPECIES: SIR2 family NAD-dependent protein deacylase

LOCUS       WP_003112491             250 aa            linear   BCT 24-DEC-2024
            [Pseudomonas].
ACCESSION   WP_003112491
VERSION     WP_003112491.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 250)
  AUTHORS   North,B.J. and Verdin,E.
  TITLE     Sirtuins: Sir2-related NAD-dependent protein deacetylases
  JOURNAL   Genome Biol 5 (5), 224 (2004)
   PUBMED   15128440
REFERENCE   2  (residues 1 to 250)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem Biophys Res Commun 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   3  (residues 1 to 250)
  AUTHORS   Brachmann,C.B., Sherman,J.M., Devine,S.E., Cameron,E.E., Pillus,L.
            and Boeke,J.D.
  TITLE     The SIR2 gene family, conserved from bacteria to humans, functions
            in silencing, cell cycle progression, and chromosome stability
  JOURNAL   Genes Dev 9 (23), 2888-2902 (1995)
   PUBMED   7498786
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10105453
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..250
                     /product="SIR2 family NAD-dependent protein deacylase"
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0017136 - histone deacetylase activity,
                     NAD-dependent [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /calculated_mol_wt=26523
     Region          12..244
                     /region_name="SIRT5_Af1_CobB"
                     /note="Eukaryotic, archaeal and prokaryotic group (class3)
                     which includes human sirtuin SIRT5, Archaeoglobus fulgidus
                     Sir2-Af1, and E. coli CobB; and are members of the SIR2
                     family of proteins, silent information regulator 2 (Sir2)
                     enzymes which catalyze NAD...; cd01412"
                     /db_xref="CDD:238703"
     Site            order(21,23..24,31..32,80,98..99,101,116,192,197,219..220,
                     235)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(100,116,164,166..170,196..198)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(124,127,152,155)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238703"
ORIGIN      
        1 mravvellag arrlviftga gvsaesgipt frdalgglwa rydpaalatp aafaddpalv
       61 wgwyewrrlk vlgvqpnpah raiaalsgri antrlvtqnv ddlheragsr dvlhlhgslh
      121 aprcatcaaa yrdalpdsve peegrriepp rcpacggqvr pgvvwfgeal peaalreafa
      181 aacecdllls vgtsgvvqpa aripglaleh gasvvhvnpq pvrtrhpreh clvgpagevl
      241 pellrrafpg