MULTISPECIES: MDR family MFS transporter [Pseudomonas].

LOCUS       WP_003112450             409 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_003112450
VERSION     WP_003112450.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Kumar,S., He,G., Kakarla,P., Shrestha,U., Ranjana,K.C.,
            Ranaweera,I., Willmon,T.M., Barr,S.R., Hernandez,A.J. and
            Varela,M.F.
  TITLE     Bacterial Multidrug Efflux Pumps of the Major Facilitator
            Superfamily as Targets for Modulation
  JOURNAL   Infect Disord Drug Targets 16 (1), 28-43 (2016)
   PUBMED   27052334
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   4  (residues 1 to 409)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13023665
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..409
                     /product="MDR family MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=43830
     Region          18..399
                     /region_name="MFS_MdtH_MDR_like"
                     /note="Multidrug resistance protein MdtH and similar
                     multidrug resistance (MDR) transporters of the Major
                     Facilitator Superfamily; cd17329"
                     /db_xref="CDD:340887"
     Site            order(28..29,32..33,36,69,119..120,122..124,127,148,
                     151..152,155,230,233..234,237..239,242,271,275,326..327,
                     331,335,351,354..355,357..358,361)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340887"
ORIGIN      
        1 msdntfsvqr fralpteihv mlvgtlltrg ayfmvwpfla lllwrefrls asaiglllal
       61 atvcgalsgi ytgwlsdrfg rkrliffgts lsglsfvllg fsgqplsygl aisgvsigca
      121 llessckali gdrvedrrsr elalycryfl inlgaalgpl igltlgvaaq agtflvtalv
      181 yfcyglllwr llhhlelkrr slaprsstgf leaclsmgrh raftllllcn mlaaliyatf
      241 dstlvqyltr sglpdvvnsi allvtinalt ivvaqfpllr llentgtggr lmlgmllmll
      301 aqlgfawtpv tlfaglalat vvlslgeliv fptfsvevdq ltpddlrgsy fgaanlyslg
      361 talaplyggi mldhagsqal ylglaalcgv imllqvgavg lrqaeragg