MULTISPECIES: MFS transporter [Pseudomonas].

LOCUS       WP_003112370             513 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_003112370
VERSION     WP_003112370.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 513)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 513)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 513)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..513
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=53000
     Region          15..443
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(20..21,24..25,28,60,110..111,113..115,118,139,
                     142..143,146,270,273..274,277..279,282,310,314,366..367,
                     371,375,391,394..395,398..399,402)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mnpsrrvalv aaiylgtfia sldisivnla lptlqyaldt dlaglqwvvd ayalclsafm
       61 lssgplsdry grkltwllgv glfsfgsllc alatslplll fgravqgiag allipgalsi
      121 ltqafhdpgq raqviggwts fsalslilgp llggllveha gwqsiflinl plgllalalg
      181 lwgieetahp ehaafdplgq llsvvwlgal tyaliaageg gwlsptawpa lllagvgllg
      241 flfverrtar pllplglfrq agfavcnlas fvlgfsgyas lfflslffqq vqgasaqqag
      301 fylapqflam galsmlfgrl qrhvplrrll vlgylvigla mlalaacgtg taypwvglll
      361 valglgmgla vpgtglavma svarersgma satmntlrqa gmavgiallg allsgraivv
      421 lgdrleglgi adaqrlatqa vtahrlpgsl agldaelpaa laegfrlaml vagasallaa
      481 allwrlrvsa gpaadtvgas grtagvqlqa drh