MATE family efflux transporter [Pseudomonas aeruginosa].

LOCUS       WP_003112342             453 aa            linear   BCT 20-MAR-2023
ACCESSION   WP_003112342
VERSION     WP_003112342.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Claxton,D.P., Jagessar,K.L. and Mchaourab,H.S.
  TITLE     Principles of Alternating Access in Multidrug and Toxin Extrusion
            (MATE) Transporters
  JOURNAL   J Mol Biol 433 (16), 166959 (2021)
   PUBMED   33774036
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Kusakizako,T., Miyauchi,H., Ishitani,R. and Nureki,O.
  TITLE     Structural biology of the multidrug and toxic compound extrusion
            superfamily transporters
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (12), 183154 (2020)
   PUBMED   31866287
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Radchenko,M., Symersky,J., Nie,R. and Lu,M.
  TITLE     Structural basis for the blockade of MATE multidrug efflux pumps
  JOURNAL   Nat Commun 6, 7995 (2015)
   PUBMED   26246409
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10192094
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     Protein         1..453
                     /product="MATE family efflux transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /calculated_mol_wt=48519
     Region          13..436
                     /region_name="MATE_DinF_like"
                     /note="DinF and similar proteins, a subfamily of the
                     multidrug and toxic compound extrusion (MATE)-like
                     proteins; cd13136"
                     /db_xref="CDD:240541"
ORIGIN      
        1 msllrdawrh apthhrvwal agpmilsnvs vplvhlvdst vvghlphayq lgavavggsl
       61 ytlmvgvlgf lrmgttgfaa qaagrddgga lrlilaqglg malllalllg alalplsgwa
      121 lqlmqpsael tgearaffht rllglpaala syalvgwflg tqnaraplai llttnlsnia
      181 lvlwfvhgld wgvqgaaras vlaewsgall glaltrrdla rrpgraqwqr lrhwlswlpl
      241 lmvnrdifir slalqlvffl ltvqgtrlgd ttvaanalll ngllltsyal dglahaveal
      301 cghaigardr aalrralvva ggwsllasla faalfalfgh lfidlqsdia gvrevayayl
      361 pylaclpllg mwsylldglf igatraremr namlvavaas lplgwllqgl gnhglwlafl
      421 afmllrglvl aaygwrltrr dgwfpaqgad sgr