MULTISPECIES: 5-carboxymethyl-2-hydroxymuconate semialdehyde

LOCUS       WP_003110130             486 aa            linear   BCT 20-NOV-2023
            dehydrogenase [Pseudomonas].
ACCESSION   WP_003110130
VERSION     WP_003110130.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Nordlund,I. and Shingler,V.
  TITLE     Nucleotide sequences of the meta-cleavage pathway enzymes
            2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic
            semialdehyde hydrolase from Pseudomonas CF600
  JOURNAL   Biochim. Biophys. Acta 1049 (2), 227-230 (1990)
   PUBMED   2194577
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02299.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..486
                     /gene="hpaE"
     Protein         1..486
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /GO_function="GO:0018480 -
                     5-carboxymethyl-2-hydroxymuconic-semialdehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:1901023 - 4-hydroxyphenylacetate catabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=52867
     Region          19..474
                     /region_name="ALDH_F8_HMSADH"
                     /note="Human aldehyde dehydrogenase family 8 member
                     A1-like; cd07093"
                     /db_xref="CDD:143412"
     Site            order(143..145,151,169,171..172,202,206..207,221..223,226,
                     229,242..243,276,380,382,446)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143412"
     Site            order(146,242,273,276)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143412"
ORIGIN      
        1 mikhwingre veskdvfeny npatgelige vasggaaeid aavaaareaf pkwantpake
       61 rarlmrrlge lidrnvphla eletldtglp ihqtknvlip rashnfeffa evctrmnghs
      121 ypvddqmlny tlyqpvgvcg lvspwnvpfm tatwktapcl algntavlkm selspltane
      181 lgrlvheagi ppgvfnvvqg ygasagdalv rhrdvravsf tggtatgrri meaagikkys
      241 melggkspvl vfedadlera ldaalftifs lngerctags rifvqesvyp qfvaefaara
      301 rrlivgdpqd pktqvgsmit qahydkvtgy irigleegat lvagglerpa glpahlskgq
      361 fiqptvfadv dnrmriaqee ifgpvvclip fkdeaealrl andveyglas yiwtqdigka
      421 hrlargieag mvfinsqnvr dlrqpfggvk asgtgregge ysfevfaeik nvcismgshh
      481 iprwgv