MULTISPECIES: rhomboid family intramembrane serine protease

LOCUS       WP_003104987             286 aa            linear   BCT 02-MAR-2025
            [Pseudomonas].
ACCESSION   WP_003104987
VERSION     WP_003104987.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 286)
  AUTHORS   Brossier,F., Jewett,T.J., Sibley,L.D. and Urban,S.
  TITLE     A spatially localized rhomboid protease cleaves cell surface
            adhesins essential for invasion by Toxoplasma
  JOURNAL   Proc Natl Acad Sci U S A 102 (11), 4146-4151 (2005)
   PUBMED   15753289
REFERENCE   2  (residues 1 to 286)
  AUTHORS   Urban,S. and Wolfe,M.S.
  TITLE     Reconstitution of intramembrane proteolysis in vitro reveals that
            pure rhomboid is sufficient for catalysis and specificity
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 1883-1888 (2005)
   PUBMED   15684070
REFERENCE   3  (residues 1 to 286)
  AUTHORS   Koonin,E.V., Makarova,K.S., Rogozin,I.B., Davidovic,L.,
            Letellier,M.C. and Pellegrini,L.
  TITLE     The rhomboids: a nearly ubiquitous family of intramembrane serine
            proteases that probably evolved by multiple ancient horizontal gene
            transfers
  JOURNAL   Genome Biol 4 (3), R19 (2003)
   PUBMED   12620104
REFERENCE   4  (residues 1 to 286)
  AUTHORS   Urban,S., Lee,J.R. and Freeman,M.
  TITLE     Drosophila rhomboid-1 defines a family of putative intramembrane
            serine proteases
  JOURNAL   Cell 107 (2), 173-182 (2001)
   PUBMED   11672525
REFERENCE   5  (residues 1 to 286)
  AUTHORS   Bier,E., Jan,L.Y. and Jan,Y.N.
  TITLE     rhomboid, a gene required for dorsoventral axis establishment and
            peripheral nervous system development in Drosophila melanogaster
  JOURNAL   Genes Dev 4 (2), 190-203 (1990)
   PUBMED   2110920
  REMARK    Erratum:[Genes Dev 1990 Apr;4(4):680-1]
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF013827.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF01694.27
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..286
                     /product="rhomboid family intramembrane serine protease"
                     /EC_number="3.4.21.105"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /calculated_mol_wt=31688
     Region          18..265
                     /region_name="rhombo_GlpG"
                     /note="rhomboid family protease GlpG; TIGR04239"
                     /db_xref="CDD:275075"
ORIGIN      
        1 msavqvlkfp lsvdlagfvg llrrlnvphr vseesgqqvl wvpderlaeq vrelyrrype
       61 gdpqatleaa prpagqgfvr qlrmspmtaa vllltfvvaa vtylgdnfat mrwltfqdfr
      121 iqgqyalftp laeslaagqw wrlftpmlih fgwlhlamna mwfwelgrri efrqgrpmll
      181 gltllfglvs nvvqyavsga slfgglsgvl ygllghcwif qylapnqayr lprgvvamml
      241 iwllvclsgv idllgfgsia ngahvggllv gclsgllggl larrrr