MULTISPECIES: CoA-acylating methylmalonate-semialdehyde

LOCUS       WP_003104350             497 aa            linear   BCT 25-JUL-2024
            dehydrogenase [Pseudomonas].
ACCESSION   WP_003104350
VERSION     WP_003104350.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 497)
  AUTHORS   Stines-Chaumeil,C., Talfournier,F. and Branlant,G.
  TITLE     Mechanistic characterization of the MSDH (methylmalonate
            semialdehyde dehydrogenase) from Bacillus subtilis
  JOURNAL   Biochem J 395 (1), 107-115 (2006)
   PUBMED   16332250
REFERENCE   2  (residues 1 to 497)
  AUTHORS   Yoshida,K.I., Aoyama,D., Ishio,I., Shibayama,T. and Fujita,Y.
  TITLE     Organization and transcription of the myo-inositol operon, iol, of
            Bacillus subtilis
  JOURNAL   J Bacteriol 179 (14), 4591-4598 (1997)
   PUBMED   9226270
REFERENCE   3  (residues 1 to 497)
  AUTHORS   Zhang,Y.X., Tang,L. and Hutchinson,C.R.
  TITLE     Cloning and characterization of a gene (msdA) encoding
            methylmalonic acid semialdehyde dehydrogenase from Streptomyces
            coelicolor
  JOURNAL   J Bacteriol 178 (2), 490-495 (1996)
   PUBMED   8550471
REFERENCE   4  (residues 1 to 497)
  AUTHORS   Kedishvili,N.Y., Popov,K.M., Rougraff,P.M., Zhao,Y., Crabb,D.W. and
            Harris,R.A.
  TITLE     CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique
            member of the aldehyde dehydrogenase superfamily. cDNA cloning,
            evolutionary relationships, and tissue distribution
  JOURNAL   J Biol Chem 267 (27), 19724-19729 (1992)
   PUBMED   1527093
REFERENCE   5  (residues 1 to 497)
  AUTHORS   Steele,M.I., Lorenz,D., Hatter,K., Park,A. and Sokatch,J.R.
  TITLE     Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO
            encoding methylmalonate-semialdehyde dehydrogenase and
            3-hydroxyisobutyrate dehydrogenase
  JOURNAL   J Biol Chem 267 (19), 13585-13592 (1992)
   PUBMED   1339433
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01722.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..497
                     /gene="mmsA"
     Protein         1..497
                     /product="CoA-acylating methylmalonate-semialdehyde
                     dehydrogenase"
                     /EC_number="1.2.1.27"
                     /GO_function="GO:0004491 - methylmalonate-semialdehyde
                     dehydrogenase (acylating, NAD) activity [Evidence IEA]"
                     /calculated_mol_wt=53532
     Region          5..481
                     /region_name="MMSDH"
                     /note="methylmalonic acid semialdehyde dehydrogenase;
                     TIGR01722"
                     /db_xref="CDD:130783"
     Site            order(62,64,68,71,75,108,111..112,121..128,133,136,139,
                     232,236,239,242,244,417,419..420,422..423,426,429..430,
                     432,434..437,446,450,452,466,473..478,480..481)
                     /site_type="other"
                     /note="tetrameric interface [polypeptide binding]"
                     /db_xref="CDD:143404"
     Site            order(148..151,159,174,177,207,224..227,230,248..250,282,
                     382,384,410)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143404"
     Site            order(151,248,279,282)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143404"
ORIGIN      
        1 msvpvrhlia gafveglgaq ripvsnpldn stlaeiacas aeqveqavas aretfaswke
       61 tpvserarvm lryqallkeh hdelakivss elgktfedak gdvwrgievv ehacnvpsll
      121 mgetvenvar nidtysitqp lgvcvgitpf nfpamiplwm fplaiacgna filkpseqvp
      181 ltsvrlaelf leagapkgvl qvvhggkeqv dqllkhpqvk avsfvgsvav gqyvyhtgta
      241 hnkrvqsfag aknhmvimpd adkaqvisnl vgasvgaagq rcmaisvavl vgaarewipe
      301 irdalakvrp gpwddsgasy gpvinpqaka rierligqgv eegaqllldg rgykvegypd
      361 gnwvgptlfa gvrpdmaiyr eevfgpvlcl aevdsleqai rlinespygn gtsiftssga
      421 aartfqhhie vgqvginipi pvplpffsft gwkgsfygdl haygkqgvrf ytetktvtar
      481 wfdsdsvagt nfsiqmr