MULTISPECIES: 2-hydroxyacid dehydrogenase [Pseudomonas].

LOCUS       WP_003104226             325 aa            linear   BCT 23-DEC-2024
ACCESSION   WP_003104226
VERSION     WP_003104226.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10143103
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..325
                     /product="2-hydroxyacid dehydrogenase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /calculated_mol_wt=35501
     Region          3..310
                     /region_name="GDH"
                     /note="D-glycerate dehydrogenase/hydroxypyruvate reductase
                     (GDH); cd05301"
                     /db_xref="CDD:240626"
     Site            order(9..10,12,52..53,73,101..102,105..106,108..109,112,
                     116,118,126,128,130,132,135..139,140..144,162..163,
                     167..168,266..267,274,280..286,288..291,293)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:240626"
     Site            order(52,74..76,99,237,284,287)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:240626"
     Site            order(75..76,103,152..156,175..177,180,207..209,213..214,
                     235..237,261..262,284,286..287)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:240626"
ORIGIN      
        1 mkknvfvfsr lapehlerlq cqfnvrvlep kqgdidaqya aalpdthgmi gvgrplgarq
       61 leqakqlevi ssvsvgydny dldylnrrgi altntpdvlt ettadlgfal lisaarrvae
      121 ldawvkagnw krtvdapqfg tdvhgkklgi lglgrigaai arrgrfgfgm qvlyhgnnrk
      181 peleqelgar flgfdellge adfvcvvvpl gaqtrqliga relglmkpsa ilvnvargqv
      241 vdeaalvaal rekrilgagl dvyekeplae splfaldnvv tlphigsath etrramaera
      301 lqnfeaalrg erpldlvnpq vwrrg