MULTISPECIES: Cd(II)/Pb(II)-responsive transcriptional regulator

LOCUS       WP_003103716             156 aa            linear   BCT 20-NOV-2023
            [Pseudomonas].
ACCESSION   WP_003103716
VERSION     WP_003103716.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 156)
  AUTHORS   Changela,A., Chen,K., Xue,Y., Holschen,J., Outten,C.E.,
            O'Halloran,T.V. and Mondragon,A.
  TITLE     Molecular basis of metal-ion selectivity and zeptomolar sensitivity
            by CueR
  JOURNAL   Science 301 (5638), 1383-1387 (2003)
   PUBMED   12958362
REFERENCE   2  (residues 1 to 156)
  AUTHORS   Borremans,B., Hobman,J.L., Provoost,A., Brown,N.L. and van Der
            Lelie,D.
  TITLE     Cloning and functional analysis of the pbr lead resistance
            determinant of Ralstonia metallidurans CH34
  JOURNAL   J. Bacteriol. 183 (19), 5651-5658 (2001)
   PUBMED   11544228
REFERENCE   3  (residues 1 to 156)
  AUTHORS   Lee,S.W., Glickmann,E. and Cooksey,D.A.
  TITLE     Chromosomal locus for cadmium resistance in Pseudomonas putida
            consisting of a cadmium-transporting ATPase and a MerR family
            response regulator
  JOURNAL   Appl. Environ. Microbiol. 67 (4), 1437-1444 (2001)
   PUBMED   11282588
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02047.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..156
                     /gene="cadR"
     Protein         1..156
                     /product="Cd(II)/Pb(II)-responsive transcriptional
                     regulator"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription
                     factor activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045893 - positive regulation of
                     transcription, DNA-templated [Evidence IEA]"
                     /calculated_mol_wt=17563
     Region          1..127
                     /region_name="HTH_CadR-PbrR"
                     /note="Helix-Turn-Helix DNA binding domain of the CadR and
                     PbrR transcription regulators; cd04784"
                     /db_xref="CDD:133411"
     Site            order(2..4,18,35..37)
                     /site_type="DNA binding"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:133411"
     Site            order(49,52,56..57,66,77..78,81,84,88,94,98,101..102,109,
                     114..115,121,123)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:133411"
     Site            order(77,112,121)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:133411"
ORIGIN      
        1 mkigelakrt gcpvetiryy eregllpepa rsegnyrqyt lahverlsfi rhcrsldmtq
       61 eeirtllalr drpeadcgta nrlidehlhh vevriaelqa lreqlrdlgs rctvagnsqa
      121 cgilreleqp aplspiaeec aeaghmhvpg vhrrhg