MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

LOCUS       WP_003103104             448 aa            linear   BCT 04-JUN-2024
            [Pseudomonas].
ACCESSION   WP_003103104
VERSION     WP_003103104.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 448)
  AUTHORS   Kouidmi,I., Levesque,R.C. and Paradis-Bleau,C.
  TITLE     The biology of Mur ligases as an antibacterial target
  JOURNAL   Mol Microbiol 94 (2), 242-253 (2014)
   PUBMED   25130693
REFERENCE   2  (residues 1 to 448)
  AUTHORS   Bertrand,J.A., Auger,G., Martin,L., Fanchon,E., Blanot,D., Le
            Beller,D., van Heijenoort,J. and Dideberg,O.
  TITLE     Determination of the MurD mechanism through crystallographic
            analysis of enzyme complexes
  JOURNAL   J Mol Biol 289 (3), 579-590 (1999)
   PUBMED   10356330
REFERENCE   3  (residues 1 to 448)
  AUTHORS   Bertrand,J.A., Auger,G., Fanchon,E., Martin,L., Blanot,D., van
            Heijenoort,J. and Dideberg,O.
  TITLE     Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate
            ligase from Escherichia coli
  JOURNAL   EMBO J 16 (12), 3416-3425 (1997)
   PUBMED   9218784
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01087.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..448
                     /gene="murD"
     Protein         1..448
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /EC_number="6.3.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /calculated_mol_wt=47949
     Region          12..448
                     /region_name="MurD"
                     /note="UDP-N-acetylmuramoylalanine-D-glutamate ligase
                     [Cell wall/membrane/envelope biogenesis]; COG0771"
                     /db_xref="CDD:440534"
ORIGIN      
        1 msliasdhfr ivvglgksgm slvrylarrg lpfavvdtre nppelatlra qypqvevrcg
       61 eldaeflcsa relyvspgls lrtpalvqaa akgvrisgdi dlfareakap ivaitgsnak
      121 stvttlvgem avaadkrvav ggnlgtpald lladdielyv lelssfqlet cdrlnaevat
      181 vlnvsedhmd rydgmadyhl akhrifrgar qvvvnradal trpliadtvp cwsfglnkpd
      241 fkafglieed gqkwlafqfd kllpvgelki rgahnysnal aalalghavg lpfdamlgal
      301 kafsglahrc qwvrerqgvs yyddskatnv gaalaaiegl gadidgklvl laggdgkgad
      361 fhdlrepvar fcravvllgr dagliaqalg navplvrvat ldeavrqaae laregdavll
      421 spacasldmf knfeergrlf akaveela