MULTISPECIES: response regulator [Pseudomonas].

LOCUS       WP_003102481             447 aa            linear   BCT 18-FEB-2025
ACCESSION   WP_003102481
VERSION     WP_003102481.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 447)
  AUTHORS   Rinaldo,S., Paiardini,A., Stelitano,V., Brunotti,P., Cervoni,L.,
            Fernicola,S., Protano,C., Vitali,M., Cutruzzola,F. and Giardina,G.
  TITLE     Structural basis of functional diversification of the HD-GYP domain
            revealed by the Pseudomonas aeruginosa PA4781 protein, which
            displays an unselective bimetallic binding site
  JOURNAL   J Bacteriol 197 (8), 1525-1535 (2015)
   PUBMED   25691523
REFERENCE   2  (residues 1 to 447)
  AUTHORS   Galperin,M.Y.
  TITLE     Diversity of structure and function of response regulator output
            domains
  JOURNAL   Curr Opin Microbiol 13 (2), 150-159 (2010)
   PUBMED   20226724
REFERENCE   3  (residues 1 to 447)
  AUTHORS   Francis,S.H., Turko,I.V. and Corbin,J.D.
  TITLE     Cyclic nucleotide phosphodiesterases: relating structure and
            function
  JOURNAL   Prog Nucleic Acid Res Mol Biol 65, 1-52 (2001)
   PUBMED   11008484
REFERENCE   4  (residues 1 to 447)
  AUTHORS   Aravind,L. and Koonin,E.V.
  TITLE     The HD domain defines a new superfamily of metal-dependent
            phosphohydrolases
  JOURNAL   Trends Biochem Sci 23 (12), 469-472 (1998)
   PUBMED   9868367
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11465815
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..447
                     /product="response regulator"
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0071111 - cyclic-guanylate-specific
                     phosphodiesterase activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /calculated_mol_wt=50627
     Region          15..132
                     /region_name="REC_HupR-like"
                     /note="phosphoacceptor receiver (REC) domain of hydrogen
                     uptake protein regulator (HupR) and similar domains;
                     cd17569"
                     /db_xref="CDD:381113"
     Site            order(98,102,105..106,109,111..113)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381113"
     Region          <229..369
                     /region_name="HDGYP"
                     /note="HD-GYP domain, c-di-GMP phosphodiesterase class II
                     (or its inactivated variant) [Signal transduction
                     mechanisms]; COG2206"
                     /db_xref="CDD:441808"
ORIGIN      
        1 mndsappsne teirfsvllv ddeplilssl rrllrnqpyd lllaesgeqa lqllesrpvd
       61 lvvsdarmpn mdgaallaei hrrspetiri lltghadlpt iakainegri hhylskpwnd
      121 dellltlrqs leylhserer rrlerltqeq ndrlqqlnat lekrvqarta elqqtadmld
      181 layeelkrsy vvgtevfsll vnqrlpkdkq tnqqiielvr accasglvde sdgrdlamaa
      241 alynigklsw ndtllsspsd llyhhdrdrf rgypelsesl lmslepmqda arlirhhqeh
      301 wdgsgypdhl kgeaiplgsr llklavdfve lqrglilerr mnrdealmyi rkyagrlydp
      361 eliepfiqvc attladvtla dpqvrahgtr dlvpgmvlar nltanngmll lnagkvlnla
      421 liekliafea iegarytlfv rlpestt