MULTISPECIES: LysR family transcriptional regulator AmpR

LOCUS       WP_003101291             296 aa            linear   BCT 20-NOV-2023
            [Pseudomonas].
ACCESSION   WP_003101291
VERSION     WP_003101291.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 296)
  AUTHORS   Dik,D.A., Dominguez-Gil,T., Lee,M., Hesek,D., Byun,B.,
            Fishovitz,J., Boggess,B., Hellman,L.M., Fisher,J.F., Hermoso,J.A.
            and Mobashery,S.
  TITLE     Muropeptide Binding and the X-ray Structure of the Effector Domain
            of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa
  JOURNAL   J. Am. Chem. Soc. 139 (4), 1448-1451 (2017)
   PUBMED   28079369
REFERENCE   2  (residues 1 to 296)
  AUTHORS   Balasubramanian,D., Schneper,L., Merighi,M., Smith,R.,
            Narasimhan,G., Lory,S. and Mathee,K.
  TITLE     The regulatory repertoire of Pseudomonas aeruginosa AmpC
            ss-lactamase regulator AmpR includes virulence genes
  JOURNAL   PLoS ONE 7 (3), e34067 (2012)
   PUBMED   22479525
REFERENCE   3  (residues 1 to 296)
  AUTHORS   Kong,K.F., Jayawardena,S.R., Indulkar,S.D., Del Puerto,A.,
            Koh,C.L., Hoiby,N. and Mathee,K.
  TITLE     Pseudomonas aeruginosa AmpR is a global transcriptional factor that
            regulates expression of AmpC and PoxB beta-lactamases, proteases,
            quorum sensing, and other virulence factors
  JOURNAL   Antimicrob. Agents Chemother. 49 (11), 4567-4575 (2005)
   PUBMED   16251297
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR012252
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..296
                     /gene="ampR"
     Protein         1..296
                     /product="LysR family transcriptional regulator AmpR"
                     /calculated_mol_wt=32472
     Region          8..67
                     /region_name="HTH_1"
                     /note="Bacterial regulatory helix-turn-helix protein, lysR
                     family; pfam00126"
                     /db_xref="CDD:459683"
     Region          95..285
                     /region_name="PBP2_LTTR_beta_lactamase"
                     /note="The C-terminal substrate-domain of LysR-type
                     transcriptional regulators for beta-lactamase genes,
                     contains the type 2 periplasmic binding fold; cd08484"
                     /db_xref="CDD:176173"
     Site            order(95..102,104..121,123..129)
                     /site_type="other"
                     /note="putative dimerization interface [polypeptide
                     binding]"
                     /db_xref="CDD:176173"
     Site            order(101..102,104,219..221,241)
                     /site_type="other"
                     /note="putative substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:176173"
ORIGIN      
        1 mvrphlplna lrafeasarh lsftraaiel cvtqaavshq vksleerlgv alfkrlprgl
       61 mlthegesll pvlcdsfdri agllerfegg hyrdvltvga vgtftvgwll prledfqarh
      121 pfidlrlsth nnrvdiaaeg ldyairfggg awhgtealal feapltvlcc pevaaqlhsp
      181 adllqhtllr syradewplw fqaaglpaha pltrsivfdt slamleaarq gvgvalapaa
      241 mfarqlases irrpfatevs tgsywltrlq srgetsamla frgwllemaa veargr