MULTISPECIES: hydroxymethylpyrimidine/phosphomethylpyrimidine

LOCUS       WP_003100335             265 aa            linear   BCT 23-JUL-2024
            kinase [Pseudomonas].
ACCESSION   WP_003100335
VERSION     WP_003100335.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Cheng,G., Bennett,E.M., Begley,T.P. and Ealick,S.E.
  TITLE     Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine
            phosphate kinase from Salmonella typhimurium at 2.3 A resolution
  JOURNAL   Structure 10 (2), 225-235 (2002)
   PUBMED   11839308
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10792784
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..265
                     /product="hydroxymethylpyrimidine/phosphomethylpyrimidine
                     kinase"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=27848
     Region          4..265
                     /region_name="PRK06427"
                     /note="bifunctional hydroxy-methylpyrimidine kinase/
                     hydroxy-phosphomethylpyrimidine kinase; Reviewed"
                     /db_xref="CDD:180561"
     Site            order(9,16,18..19,21,25,28..29,32,35..40,42,45..49,54..55,
                     57,59..60,63,66,70..71)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238574"
     Site            order(15,27,48,84,212)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238574"
     Site            order(109,146,175,209,211)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238574"
ORIGIN      
        1 mktptsrpvv lclsghdpsg gaglqadiea llaqgchaap avtaltvqdt vnvsdfrvld
       61 rewvlaqana vladlpvaav klgmlgslem vdtvaeilaa hphlpvvcdp vlraggggal
      121 gkgdvgfamr erllpratia tpnlpearll adlpegsadq caerllehce hllitgghgd
      181 esevhnrlys rdgsrrtftc qrlpgsyhgs gctlasalag rialgealhg avqsaldytw
      241 rtlrdaespg hgqyvprrlp tdfch