MULTISPECIES: N-acetylmuramate alpha-1-phosphate

LOCUS       WP_003099549             224 aa            linear   BCT 03-MAR-2024
            uridylyltransferase MurU [Pseudomonas].
ACCESSION   WP_003099549
VERSION     WP_003099549.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Renner-Schneck,M., Hinderberger,I., Gisin,J., Exner,T., Mayer,C.
            and Stehle,T.
  TITLE     Crystal Structure of the N-Acetylmuramic Acid alpha-1-Phosphate
            (MurNAc-alpha1-P) Uridylyltransferase MurU, a Minimal Sugar
            Nucleotidyltransferase and Potential Drug Target Enzyme in
            Gram-negative Pathogens
  JOURNAL   J Biol Chem 290 (17), 10804-10813 (2015)
   PUBMED   25767118
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Borisova,M., Gisin,J. and Mayer,C.
  TITLE     Blocking peptidoglycan recycling in Pseudomonas aeruginosa
            attenuates intrinsic resistance to fosfomycin
  JOURNAL   Microb Drug Resist 20 (3), 231-237 (2014)
   PUBMED   24819062
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Gisin,J., Schneider,A., Nagele,B., Borisova,M. and Mayer,C.
  TITLE     A cell wall recycling shortcut that bypasses peptidoglycan de novo
            biosynthesis
  JOURNAL   Nat Chem Biol 9 (8), 491-493 (2013)
   PUBMED   23831760
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF045761.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..224
                     /gene="murU"
     Protein         1..224
                     /product="N-acetylmuramate alpha-1-phosphate
                     uridylyltransferase MurU"
                     /EC_number="2.7.7.99"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=24018
     Region          2..222
                     /region_name="GCD1"
                     /note="NDP-sugar pyrophosphorylase, includes eIF-2Bgamma,
                     eIF-2Bepsilon, and LPS biosynthesis protein s
                     [Translation, ribosomal structure and biogenesis, Cell
                     wall/membrane/envelope biogenesis]; COG1208"
                     /db_xref="CDD:440821"
ORIGIN      
        1 mkamilaagr germrpttlh tpkplieaag vplierqlla lrqagvddwv inhawlgeqi
       61 eaylgdgsrl ggriayspeg epletgggif ralpllgeqp flllngdvws dfdysrlhla
      121 dgdlahlvlv dnpahhpagd fhldaggrvg etreaggnlt ysgiavlhpa lfegcqpgaf
      181 klapllrkai aagrvsgehh rgqwvdvgth erlaeverll aeha