MULTISPECIES: c-di-GMP-binding multidrug transporter

LOCUS       WP_003095496             270 aa            linear   BCT 20-NOV-2023
            transcriptional regulator BrlR [Pseudomonas].
ACCESSION   WP_003095496
VERSION     WP_003095496.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 270)
  AUTHORS   Raju,H. and Sharma,R.
  TITLE     Crystal structure of BrlR with c-di-GMP
  JOURNAL   Biochem. Biophys. Res. Commun. 490 (2), 260-264 (2017)
   PUBMED   28619510
REFERENCE   2  (residues 1 to 270)
  AUTHORS   Chambers,J.R., Liao,J., Schurr,M.J. and Sauer,K.
  TITLE     BrlR from Pseudomonas aeruginosa is a c-di-GMP-responsive
            transcription factor
  JOURNAL   Mol. Microbiol. 92 (3), 471-487 (2014)
   PUBMED   24612375
REFERENCE   3  (residues 1 to 270)
  AUTHORS   Liao,J. and Sauer,K.
  TITLE     The MerR-like transcriptional regulator BrlR contributes to
            Pseudomonas aeruginosa biofilm tolerance
  JOURNAL   J. Bacteriol. 194 (18), 4823-4836 (2012)
   PUBMED   22730129
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR000497
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..270
                     /gene="brlR"
     Protein         1..270
                     /product="c-di-GMP-binding multidrug transporter
                     transcriptional regulator BrlR"
                     /calculated_mol_wt=31037
     Region          2..112
                     /region_name="HTH_BmrR"
                     /note="Helix-Turn-Helix DNA binding domain of the BmrR
                     transcription regulator; cd01107"
                     /db_xref="CDD:133382"
     Site            order(3..5,19,37..39)
                     /site_type="DNA binding"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:133382"
     Site            40
                     /site_type="other"
                     /note="drug binding residues [chemical binding]"
                     /db_xref="CDD:133382"
     Site            order(51,54,58..59,68,84,88,94,98,101..102)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:133382"
     Region          120..269
                     /region_name="YdeE"
                     /note="Predicted transcriptional regulator YdeE, contains
                     AraC-type DNA-binding domain [Transcription]; COG3708"
                     /db_xref="CDD:442922"
ORIGIN      
        1 mltigqlari feistktlrh ydaiglfvpa rtgsdngyry yqpeqieqls rilalrrldv
       61 pleaidrlkr dgalddpqrl rhflqrhqht lreeisarqr llaeldrtla tlahwrirnm
      121 hariverpaf svvgmeyfgs apgdtigqlw erfiprehei agkhdpevsy gicaqqpnge
      181 fhyvagfevq egwpvpegmv rfqvpaqkya vfthkgtapq iaesfqaiys hllaerglep
      241 kagvdfeyyd qrfrgpldpn sqvdlyipiy