MULTISPECIES: carbamoyl-phosphate synthase large subunit

LOCUS       WP_003095207            1073 aa            linear   BCT 07-MAY-2024
            [Pseudomonas].
ACCESSION   WP_003095207
VERSION     WP_003095207.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 1073)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J Biol Chem 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
REFERENCE   5  (residues 1 to 1073)
  AUTHORS   Trotta,P.P., Pinkus,L.M., Haschemeyer,R.H. and Meister,A.
  TITLE     Reversible dissociation of the monomer of glutamine-dependent
            carbamyl phosphate synthetase into catalytically active heavy and
            light subunits
  JOURNAL   J Biol Chem 249 (2), 492-499 (1974)
   PUBMED   4358555
REFERENCE   6  (residues 1 to 1073)
  AUTHORS   Khedouri,E., Anderson,P.M. and Meister,A.
  TITLE     Selective inactivation of the glutamine binding site of Escherichia
            coli carbamyl phosphate synthetase by
            2-amino-4-oxo-5-chloropentanoic acid
  JOURNAL   Biochemistry 5 (11), 3552-3557 (1966)
   PUBMED   5339592
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003671.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05294
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..1073
                     /gene="carB"
     Protein         1..1073
                     /product="carbamoyl-phosphate synthase large subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence
                     IEA]"
                     /calculated_mol_wt=117201
     Region          1..1068
                     /region_name="carB"
                     /note="carbamoyl-phosphate synthase large subunit;
                     PRK05294"
                     /db_xref="CDD:235393"
ORIGIN      
        1 mpkrtdiksi lilgagpivi gqacefdysg aqackalree gyrvilvnsn patimtdpam
       61 adatyiepik watvakiiek erpdallptm ggqtalncal dlerhgvlek fgvemigana
      121 dtidkaedrs rfdkamkdig lacprsgiah smeeaygvle qvgfpciirp sftmggtggg
      181 iaynreefee icargldlsp tnellidesl igwkeyemev vrdkkdncii vcsienfdpm
      241 gvhtgdsitv apaqtltdke yqimrnasla vlreigvetg gsnvqfgicp ntgrmvviem
      301 nprvsrssal askatgfpia kiaaklavgy tldelqndit ggrtpasfep aidyvvtkip
      361 rfafekfpka darlttqmks vgevmaigrt fqesvqkalr glevgatgfd pkldlndpea
      421 dsilkreltv psaervwyva dafragksve evfeltride wflvqiedlv kdeekvktlg
      481 lssidrelmy klkrkgfsda rlakllgvte knlrshrhkl kvlpvykrvd tcaaefatdt
      541 aymystyeee ceanpssrek imilgggpnr igqgiefdyc cvhaalamre dgyetimvnc
      601 npetvstdyd tsdrlyfepv tledvleivr veqpkgvivq yggqtplklc raleeagvpi
      661 igtspdaidr aedrerfqqm vqrlnlrqpa natarsedea laaskaigyp lvvrpsyvlg
      721 grameivyqe eelkrymrea vqvsndspvl ldhflncaie vdidavcdge ivvigaimqh
      781 ieqagvhsgd sacslppysl pqhiqdeire qvkkmalelg vvglmnvqma vqgedifvie
      841 vnprasrtvp fvskcvgesl akvaarvmag ktlaevgftq eiippffsvk eavfpfakfp
      901 gvdpilgpem kstgevmgvg dsfaeafaka qlgaseilpt agcafisvre ddkpfaaqva
      961 gdlvalgfev vatagtarvi eaaglpvrrv nkvtegrphv vdmikndevt liinttegrq
     1021 siadsysirr nalqhkicct ttiaggqaic ealkfgpekt vrrlqdlhag ika