MULTISPECIES: MFS transporter [Pseudomonas].

LOCUS       WP_003094912             403 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_003094912
VERSION     WP_003094912.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 12947616
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..403
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=42602
     Region          14..392
                     /region_name="MFS_MefA_like"
                     /note="Macrolide efflux protein A and similar proteins of
                     the Major Facilitator Superfamily of transporters;
                     cd06173"
                     /db_xref="CDD:340863"
     Site            order(24..25,28..29,32,64,119..120,122..124,127,147,
                     150..151,154,226,229..230,233..235,238,262,266,319..320,
                     324,328,344,347..348,351..352,355)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340863"
ORIGIN      
        1 mssqpssllr hrpflafwla rvctasgfqm ltvaigwhiy eltgnvldlg lvglveflpr
       61 vlfmlhtghv adrydrrria alcqagqalv avalvlgaas geitrnmifv lafalgtara
      121 fempttqall pnlvpaglfp ravaasasam qaatiaapal ggllyafgas wvyvptatly
      181 vlacvltlsl pvrnqpltqg katldsllag irfirsrpdi fgaisldlfa vllggatall
      241 pvfakdillt gpwglgllrs apavgalams fwlahfsier nvgrimflsv gifglatiaf
      301 glsksfwlsl gvlvvlgaad mvsmvirgaf vqletpdemr grvsavnglf igasnqlgef
      361 esgltahwfg tvpavvlggi gtlvvtgawm klfpslaqrd rlh