MULTISPECIES: lipid A hydroxylase LpxO [Pseudomonas].

LOCUS       WP_003094463             299 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_003094463
VERSION     WP_003094463.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 299)
  AUTHORS   Llobet,E., Martinez-Moliner,V., Moranta,D., Dahlstrom,K.M.,
            Regueiro,V., Tomas,A., Cano,V., Perez-Gutierrez,C., Frank,C.G.,
            Fernandez-Carrasco,H., Insua,J.L., Salminen,T.A., Garmendia,J. and
            Bengoechea,J.A.
  TITLE     Deciphering tissue-induced Klebsiella pneumoniae lipid A structure
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 112 (46), E6369-E6378 (2015)
   PUBMED   26578797
REFERENCE   2  (residues 1 to 299)
  AUTHORS   MacArthur,I., Jones,J.W., Goodlett,D.R., Ernst,R.K. and Preston,A.
  TITLE     Role of pagL and lpxO in Bordetella bronchiseptica lipid A
            biosynthesis
  JOURNAL   J. Bacteriol. 193 (18), 4726-4735 (2011)
   PUBMED   21764941
REFERENCE   3  (residues 1 to 299)
  AUTHORS   Moskowitz,S.M. and Ernst,R.K.
  TITLE     The role of Pseudomonas lipopolysaccharide in cystic fibrosis
            airway infection
  JOURNAL   Subcell. Biochem. 53, 241-253 (2010)
   PUBMED   20593270
REFERENCE   4  (residues 1 to 299)
  AUTHORS   Gibbons,H.S., Reynolds,C.M., Guan,Z. and Raetz,C.R.
  TITLE     An inner membrane dioxygenase that generates the 2-hydroxymyristate
            moiety of Salmonella lipid A
  JOURNAL   Biochemistry 47 (9), 2814-2825 (2008)
   PUBMED   18254598
REFERENCE   5  (residues 1 to 299)
  AUTHORS   Gibbons,H.S., Lin,S., Cotter,R.J. and Raetz,C.R.
  TITLE     Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate
            moiety in Salmonella typhimurium lipid A. Function of LpxO, A new
            Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue
  JOURNAL   J. Biol. Chem. 275 (42), 32940-32949 (2000)
   PUBMED   10903325
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF033391.2
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..299
                     /gene="lpxO"
     Protein         1..299
                     /product="lipid A hydroxylase LpxO"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /calculated_mol_wt=34554
     Region          2..298
                     /region_name="Asp_Arg_Hydrox"
                     /note="Aspartyl/Asparaginyl beta-hydroxylase; cl42444"
                     /db_xref="CDD:478204"
ORIGIN      
        1 mkvlilaaya lsilyvhfrg rvrhklsrql sdhssflapi nclmylfskv pnrpylapqt
       61 fpelqvlvdn wqairsealh lhdagnikrs eqyddigfns ffksgwkrfy lkwydeahps
      121 agqlcpqtta llrqipsvka amfaelppgs klvrhrdpya gslrfhlglf tpndpacfie
      181 vdgeryhwrd geavvfdetf ihyaenateh nriilfcdie rpltqgwata fnrwfsrnvm
      241 aaaaapnnag drtgglnrif dslykirlqg krlkkrnrkl yylqkwgffa lvlafilwi