MULTISPECIES: histidinol dehydrogenase [Pseudomonas].

LOCUS       WP_003094326             440 aa            linear   BCT 17-JUN-2024
ACCESSION   WP_003094326
VERSION     WP_003094326.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00069.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..440
                     /gene="hisD"
     Protein         1..440
                     /product="histidinol dehydrogenase"
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=47048
     Region          7..434
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(61,136,138..139,147,168,194..195,197,218..220,
                     222..223,268)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(89..90,93..94,96,99..100,103..104,107..108,115,117,
                     121..125,128,130,142..146,213,228,232,256..257,260..261,
                     263..265,267..268,338,343,346..347,349..357,359,361..362,
                     364..368,370,372,382..383,385..389,391..392,395..402,
                     417..418,420..426)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(144,146,243,268,333..334,363,367..368,374,421,423,
                     426)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(146,243,265,268,333..334,363,367..368,374,421,423,
                     426)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(265,268,367,426)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            333..334
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
ORIGIN      
        1 mtapfairrl naadpdfgrh ldhllswesv sddsvnqrvl diiaavrsrg daavveftqr
       61 fdglqaasma dlilprerle laltritvaq realevaaer vrsyhekqkq gswryteadg
      121 tvlgqqvtpl draglyvpgg kasypssvlm naipakvagv sevvmvvptp rgeineivla
      181 aaciagvdrv ftiggaqava alaygtesvp rvdkivgpgn iyvatakrhv fgqvgidmia
      241 gpseilvvcd gqtdpdwiam dlfsqaehde daqsilvspd aafldrvads iarllptmer
      301 aeiirtsleg rgaliqvadq aqacavanri apehlelsva dpeswlpeir hagaifmgry
      361 taealgdyca gpnhvlptsg tarfssplgv ydfqkrssii ncsaegasvl grtasvlarg
      421 esltaharsa eyrildekea