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MULTISPECIES: bifunctional protein-disulfide


LOCUS       WP_003092626             242 aa            linear   BCT 20-NOV-2023
            isomerase/oxidoreductase DsbC [Pseudomonas].
ACCESSION   WP_003092626
VERSION     WP_003092626.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 242)
  AUTHORS   Fabianek,R.A., Hennecke,H. and Thony-Meyer,L.
  TITLE     Periplasmic protein thiol:disulfide oxidoreductases of Escherichia
            coli
  JOURNAL   FEMS Microbiol. Rev. 24 (3), 303-316 (2000)
   PUBMED   10841975
REFERENCE   2  (residues 1 to 242)
  AUTHORS   Chen,J., Song,J.L., Zhang,S., Wang,Y., Cui,D.F. and Wang,C.C.
  TITLE     Chaperone activity of DsbC
  JOURNAL   J. Biol. Chem. 274 (28), 19601-19605 (1999)
   PUBMED   10391895
REFERENCE   3  (residues 1 to 242)
  AUTHORS   Frishman,D.
  TITLE     DSBC protein: a new member of the thioredoxin fold-containing
            family
  JOURNAL   Biochem. Biophys. Res. Commun. 219 (3), 686-689 (1996)
   PUBMED   8645242
REFERENCE   4  (residues 1 to 242)
  AUTHORS   Zapun,A., Missiakas,D., Raina,S. and Creighton,T.E.
  TITLE     Structural and functional characterization of DsbC, a protein
            involved in disulfide bond formation in Escherichia coli
  JOURNAL   Biochemistry 34 (15), 5075-5089 (1995)
   PUBMED   7536035
REFERENCE   5  (residues 1 to 242)
  AUTHORS   Bardwell,J.C.
  TITLE     Building bridges: disulphide bond formation in the cell
  JOURNAL   Mol. Microbiol. 14 (2), 199-205 (1994)
   PUBMED   7830566
REFERENCE   6  (residues 1 to 242)
  AUTHORS   Missiakas,D., Georgopoulos,C. and Raina,S.
  TITLE     The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein
            involved in disulfide bond formation
  JOURNAL   EMBO J. 13 (8), 2013-2020 (1994)
   PUBMED   8168498
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008129.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK10877
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..242
                     /gene="dsbC"
     Protein         1..242
                     /product="bifunctional protein-disulfide
                     isomerase/oxidoreductase DsbC"
                     /EC_number="5.3.4.1"
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /calculated_mol_wt=25964
     Region          1..237
                     /region_name="Protein Disulfide Oxidoreductases and Other
                     Proteins with a Thioredoxin fold"
                     /note="The thioredoxin (TRX)-like superfamily is a large,
                     diverse group of proteins containing a TRX fold. Many
                     members contain a classic TRX domain with a redox active
                     CXXC motif. They function as protein disulfide
                     oxidoreductases (PDOs), altering the redox...; cl00388"
                     /db_xref="CDD:469754"
     Site            order(39..47,50..60,62..78)
                     /site_type="other"
                     /note="dimerization domain [polypeptide binding]"
                     /db_xref="CDD:239318"
     Site            71..78
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239318"
     Site            order(130,133)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239318"
ORIGIN      
        1 mrvtrflaaa alglmstlal adnadqnirk tlqalqpdlp idsiassplq glyqvqlkgg
       61 rvlyasadgq fvmqgylyqv kdgkpvnlte kaesqaiaka ingvpasemv vypakgqaka
      121 hitvftdttc pycqklhaev pdlteqgiev rymafprqgp qsagdkqlqa vwcakeptka
      181 mdammngkei kssecknpvd kqfqmgqmvg vqgtpaivla ngqllpgyqp akqlaklale
      241 ak