MULTISPECIES: Leu/Phe/Val dehydrogenase [Pseudomonas].

LOCUS       WP_003091859             341 aa            linear   BCT 23-DEC-2024
ACCESSION   WP_003091859
VERSION     WP_003091859.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 341)
  AUTHORS   Medvedev,K.E., Kinch,L.N., Schaeffer,R.D. and Grishin,N.V.
  TITLE     Functional analysis of Rossmann-like domains reveals convergent
            evolution of topology and reaction pathways
  JOURNAL   PLoS Comput Biol 15 (12), e1007569 (2019)
   PUBMED   31869345
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 341)
  AUTHORS   Shin,W.H. and Kihara,D.
  TITLE     55 Years of the Rossmann Fold
  JOURNAL   Methods Mol Biol 1958, 1-13 (2019)
   PUBMED   30945211
REFERENCE   3  (residues 1 to 341)
  AUTHORS   Hanukoglu,I.
  TITLE     Proteopedia: Rossmann fold: A beta-alpha-beta fold at dinucleotide
            binding sites
  JOURNAL   Biochem Mol Biol Educ 43 (3), 206-209 (2015)
   PUBMED   25704928
REFERENCE   4  (residues 1 to 341)
  AUTHORS   Brunhuber,N.M. and Blanchard,J.S.
  TITLE     The biochemistry and enzymology of amino acid dehydrogenases
  JOURNAL   Crit Rev Biochem Mol Biol 29 (6), 415-467 (1994)
   PUBMED   7705101
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10500541
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     Protein         1..341
                     /product="Leu/Phe/Val dehydrogenase"
                     /EC_number="1.4.1.-"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=35502
     Region          23..130
                     /region_name="ELFV_dehydrog_N"
                     /note="Glu/Leu/Phe/Val dehydrogenase, dimerization domain;
                     pfam02812"
                     /db_xref="CDD:460706"
     Region          140..338
                     /region_name="NAD_bind_Leu_Phe_Val_DH"
                     /note="NAD(P) binding domain of leucine dehydrogenase,
                     phenylalanine dehydrogenase, and valine dehydrogenase;
                     cd01075"
                     /db_xref="CDD:133444"
     Site            order(174,176..178,197..198,202,231..232,253,255)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:133444"
     Site            285
                     /site_type="active"
                     /note="Phe binding site [active]"
                     /db_xref="CDD:133444"
ORIGIN      
        1 mfdmmdaarl eglhlaqdpa tglkaiiaih strlgpalgg crylpypnde aaigdairla
       61 qgmsykaala gleqgggkav iirpphldnr galfeafgrf ieslggryit avdsgtssad
      121 mdciaqqtrh vtsttqagdp sphtalgvfa girasaqarl gsddleglrv avqglghvgy
      181 alaeqlaavg aellvcdldp grvqlaveql gahplapeal lstpcdilap cglggvltsq
      241 svsqlrcaav agaannqler pevadelear gilyapdyvi nsggliyval khrgadphsi
      301 tahlaripar lteiyahaqa dhqspariad rlaerilygp q