MULTISPECIES: bifunctional 3-hydroxy-3-isohexenylglutaryl-CoA

LOCUS       WP_003088593             300 aa            linear   BCT 20-NOV-2023
            lyase/hydroxymethylglutaryl-CoA lyase [Pseudomonas].
ACCESSION   WP_003088593
VERSION     WP_003088593.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 300)
  AUTHORS   Chavez-Aviles,M., Diaz-Perez,A.L. and Campos-Garcia,J.
  TITLE     The bifunctional role of LiuE from Pseudomonas aeruginosa, displays
            additionally HIHG-CoA lyase enzymatic activity
  JOURNAL   Mol Biol Rep 37 (4), 1787-1791 (2010)
   PUBMED   19597963
REFERENCE   2  (residues 1 to 300)
  AUTHORS   Chavez-Aviles,M., Diaz-Perez,A.L., Reyes-de la Cruz,H. and
            Campos-Garcia,J.
  TITLE     The Pseudomonas aeruginosa liuE gene encodes the
            3-hydroxy-3-methylglutaryl coenzyme A lyase, involved in leucine
            and acyclic terpene catabolism
  JOURNAL   FEMS Microbiol Lett 296 (1), 117-123 (2009)
   PUBMED   19459965
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR013023
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..300
                     /gene="liuE"
     Protein         1..300
                     /product="bifunctional 3-hydroxy-3-isohexenylglutaryl-CoA
                     lyase/hydroxymethylglutaryl-CoA lyase"
                     /EC_number="4.1.3.26"
                     /EC_number="4.1.3.4"
                     /calculated_mol_wt=31706
     Region          3..289
                     /region_name="PRK05692"
                     /note="hydroxymethylglutaryl-CoA lyase; Provisional"
                     /db_xref="CDD:180206"
     Site            order(15..16,19,49,51,101,207,209,249)
                     /site_type="active"
                     /db_xref="CDD:163676"
     Site            order(15..16,46)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:163676"
     Site            order(16,207,209,249)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:163676"
ORIGIN      
        1 mnlpkkvrlv evgprdglqn ekqpievadk irlvddlsaa gldyievgsf vspkwvpqma
       61 gsaevfagir qrpgvtyaal apnlkgfeaa lesgvkevav faaaseafsq rnincsikds
      121 lerfvpvlea arqhqvrvrg yiscvlgcpy dgdvdprqva wvarelqqmg cyevslgdti
      181 gvgtagatrr lieavasevp rerlaghfhd tygqalaniy asllegiavf dssvaglggc
      241 pyakgatgnv asedvlylln gleihtgvdm halvdagqri cavlgksngs raakallaka