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MULTISPECIES: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA

FASTAView on NCBI
LOCUS       WP_003087475             171 aa            linear   BCT 06-NOV-2024
            [Pseudomonas].
ACCESSION   WP_003087475
VERSION     WP_003087475.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas
  ORGANISM  Pseudomonas
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae.
REFERENCE   1  (residues 1 to 171)
  AUTHORS   Hoang,T.T. and Schweizer,H.P.
  TITLE     Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and
            characterization of the fabAB operon encoding beta-hydroxyacyl-acyl
            carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier
            protein synthase I (FabB)
  JOURNAL   J Bacteriol 179 (17), 5326-5332 (1997)
   PUBMED   9286984
REFERENCE   2  (residues 1 to 171)
  AUTHORS   Heath,R.J. and Rock,C.O.
  TITLE     Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein
            dehydratases in Escherichia coli fatty acid biosynthesis
  JOURNAL   J Biol Chem 271 (44), 27795-27801 (1996)
   PUBMED   8910376
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01749.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Pseudomonas"
                     /db_xref="taxon:286"
     gene            1..171
                     /gene="fabA"
     Protein         1..171
                     /product="3-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     FabA"
                     /EC_number="4.2.1.59"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0019171 -
                     (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=18616
     Region          1..171
                     /region_name="PRK05174"
                     /note="bifunctional 3-hydroxydecanoyl-ACP
                     dehydratase/trans-2-decenoyl-ACP isomerase"
                     /db_xref="CDD:179953"
     Site            order(26..28,84,87..88,91..92,103..106)
                     /site_type="active"
                     /note="active site 1 [active]"
                     /db_xref="CDD:238614"
     Site            order(27,29,80,84,103..111,113,115..116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238614"
     Site            order(77..79,113..116)
                     /site_type="active"
                     /note="active site 2 [active]"
                     /db_xref="CDD:238614"
ORIGIN      
        1 mtkqhaftre dllrcsrgel fgpgnaqlpa pnmlmidriv hisdvggkyg kgelvaeldi
       61 npdlwffach fegdpvmpgc lgldamwqlv gfylgwqgnp grgralgsge vkffgqvlpt
      121 akkvtynihi krtinrslvl aiadgtvsvd greiysaegl rvglftstds f